Figure. 2.
Scatter plot of individual BPND estimates with the selective D2/3 antagonist [18F]fallypride and PET in young (n=6) and adult (n=5) HIV-1 Tg rats and young (n=7) and adult (n=5) control rats. The mean BPND for each region and group is indicated by a small horizontal line. The estimates of BPND in the young HIV-1 Tg rats were significantly reduced in the dorsal striatum (14%; *p<0.05) with a trend reduction in the ventral striatum (14%; p=0.11). In the older HIV-1 Tg rats, decreases were significant in the dorsal (33%; ***p<0.001) and ventral (36%; ***p<0.001) striatal ROIs compared to controls. No significant BPND reduction was observed in the thalamus of the Tg rats compared to controls, neither in the young nor in the adult groups.