Table 1.
Demographics and Clinical Characteristics of NLST Cohort Cases
| Characteristic | Lung Cancer Cases (N = 170) | Nodule-Positive Controls (N = 328) | P-value1 |
|---|---|---|---|
| Age, mean (SD) | 63.7 (5.11) | 63.5 (5.1) | 0.66 |
| Sex, N (%) | |||
| Male | 94 (55.3) | 192 (58.5) | |
| Female | 76 (44.7) | 136 (41.5) | 0.28 |
| Race, N (%) | |||
| White | 161 (94.7) | 315 (96.0) | |
| Black, Asian, Other | 9 (5.3) | 13 (4.0) | 0.49 |
| Ethnicity, N (%) | |||
| Hispanic or Latino | 0 (0.0) | 2 (0.6) | |
| Neither Hispanic/Latino and | 170 (100.0) | 326 (99.4) | 0.55 |
| Unknown | |||
| Smoking, N (%) | |||
| Current | 89 (53.4) | 175 (53.4) | |
| Former | 81 (47.6) | 153 (46.6) | 0.85 |
| Pack-Years Smoked, mean (SD) | |||
| Current smokers | 63.2 (25.8) | 62.0 (21.3) | 0.69 |
| Former smokers | 64.5 (27.6) | 63.7 (26.8) | 0.83 |
| Self-Reported History of COPD, N (%) | |||
| Yes | 13 (7.6) | 19 (5.8) | |
| No | 157 (92.4) | 309 (94.2) | 0.44 |
| FH of Lung Cancer, N (%) | |||
| Yes | 41 (24.1) | 56 (17.1) | |
| No | 129 (75.9) | 272 (82.9) | 0.07 |
| Stage, N (%) | |||
| I | 117 (68.8) | -- | |
| II | 12 (7.1) | -- | |
| III | 21 (12.3) | -- | |
| IV | 18 (10.6) | -- | |
| Carcinoid, Unknown | 2 (1.2) | -- | -- |
| Histology, N (%) | |||
| Adenocarcinoma | 108 (63.5) | -- | |
| Squamous cell carcinoma | 38 (22.4) | -- | |
| Other, NOS, Unknown | 24 (14.1) | -- | -- |
Abbreviations: COPD = chronic obstructive pulmonary disease; FH = Family history;
1
P-values calculated using Fisher’s exact test for categorical variables, Student’s t-test for continuous variables