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Overview of the yeast peroxisome-mitochondria contact site. The ERMES (endoplasmic reticulum mitochondria encounter structure) tethers mitochondria to the ER, but additionally establishes a contact between mitochondria and peroxisomes through the Mdm34-Pex11 interaction. The mitochondria-peroxisome tether might have dynamic functions in the regulation of ROS homeostasis, metabolite exchange between the two organelles, or the modulation of respiratory efficiency.
