Table 4.
Shared variables across multivariable indices predicting mortality in COPD ≤12 months
| Prognostic index | Demographic
|
Physiological
|
Exercise capacity
|
Patient reported
|
Prior history
|
||||
|---|---|---|---|---|---|---|---|---|---|
| Age | Smoking | FEV1% predicted | BMI | 6MWT distance | Dyspnea* | Quality of life SGRQ | Severe exacerbations¥ | Comorbidities | |
| ADO | ✓ | ✓ | ✓ | ||||||
| B-AE-D | ✓ | ✓ | ✓ | ||||||
| BODE | ✓ | ✓ | ✓ | ✓ | |||||
| BODEx | ✓ | ✓ | ✓ | ✓ | |||||
| eBODE | ✓ | ✓ | ✓ | ✓ | ✓ | ||||
| mBODE | ✓ | ✓ | ✓ | ✓ | |||||
| Elixhauser comorbidity | ✓ | ||||||||
| Charlson comorbidity | ✓ | ||||||||
| John Hopkin’s comorbidity | ✓ | ||||||||
| DOSE | ✓ | ✓ | ✓ | ✓ | |||||
| SAFE | ✓ | ✓ | ✓ | ✓ | |||||
Notes:
Includes different dyspnea measures: mMRC, Fletcher, and SOBQ.
Exacerbation history measured over variable time frames, either last 12 or 24 months. ADO: age, dyspnea, and obstruction; B-AE-D: BMI (B), severe AECOPD frequency (AE), mMRC dyspnea severity (D); BODE: BMI, airflow Obstruction, Dyspnea, and Exercise; DOSE: dyspnea, obstruction, smoking, exacerbation.
Abbreviations: AECOPD, acute exacerbation of COPD; BMI, body mass index; BODEx, BODE exercise capacity; FEV1, forced expiratory volume in 1 second; 6MWT, 6-minute walk test; eBODE, exacerbations BODE; mBODE, modified BODE; mMRC, modified Medical Research Council; SAFE, obstruction, exercise, quality of life and exacerbations; SGRQ, St George’s Respiratory Questionnaire; SOBQ, shortness of breath questionnaire.