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. Author manuscript; available in PMC: 2017 Aug 7.
Published in final edited form as: Cell Rep. 2017 Jul 18;20(3):655–667. doi: 10.1016/j.celrep.2017.06.080

Figure 3. Loss of hepatic fatty acid oxidation induces hepatokines.

Figure 3

(A) Western blot for mitochondrial complexes and Hsc70 in livers of Cpt2lox/lox and Cpt2L−/− mice fed a HFD for 16wks.

(B) Gene expression of fatty acid metabolism and Pparα target genes in livers of Cpt2lox/lox and Cpt2L−/− mice fed a HFD for 16wks (n=6).

(C) Liver mRNA of igfbp1, gdf15, and fgf21 in Cpt2lox/lox and Cpt2L−/− mice fed a HFD for 16wks (n=6).

(D) Serum concentrations of Igfbp1, Gdf15 and Fgf21 in Cpt2lox/lox and Cpt2L−/− mice fed a HFD for 16wks (n=6).

Data are expressed as mean ± SEM. *p<0.05; **p<0.01; ***p<0.001.