Figure 3. Loss of hepatic fatty acid oxidation induces hepatokines.

(A) Western blot for mitochondrial complexes and Hsc70 in livers of Cpt2^lox/lox and Cpt2^L−/− mice fed a HFD for 16wks.

(B) Gene expression of fatty acid metabolism and Pparα target genes in livers of Cpt2^lox/lox and Cpt2^L−/− mice fed a HFD for 16wks (n=6).

(C) Liver mRNA of igfbp1, gdf15, and fgf21 in Cpt2^lox/lox and Cpt2^L−/− mice fed a HFD for 16wks (n=6).

(D) Serum concentrations of Igfbp1, Gdf15 and Fgf21 in Cpt2^lox/lox and Cpt2^L−/− mice fed a HFD for 16wks (n=6).

Data are expressed as mean ± SEM. *p<0.05; **p<0.01; ***p<0.001.