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. Author manuscript; available in PMC: 2018 Apr 20.
Published in final edited form as: Cell. 2017 Apr 20;169(3):381–405. doi: 10.1016/j.cell.2017.04.001

Figure 3. GSK3 regulation and substrate phosphorylation.

Figure 3

GSK3 recognizes and phosphorylates substrates that are previously phosphorylated by a priming kinase. A partial list of known GSK3 substrates is shown. Akt’s phosphorylation of GSK3 inactivates it by blocking its access to primed substrates.