Table 1.

Parameters used for multidimensional analysis

Shorthand	Description	Mode	Method	Reference
Vrest	Resting membrane potential	I Clamp	Direct measurement	N/A
Cm	Membrane capacitance	I Clamp	See reference	Golowasch et al., 2009
Rm	Input resistance
Ncomps	Number of model compartments
Ih_sag	Hyperpolarization-induced depolarizing potential	I Clamp	IH,sag = Vinit − Vss	N/A
Ih_current	Hyperpolarization-induced depolarizing current	V Clamp	IH,curr = Iinit − Iss	N/A
EPSC_freq	Mean spontaneous EPSC frequency	V Clamp	Direct measurement after waveform sorting	Hendrickson et al., 2008
EPSC_amp	Mean spontaneous EPSC amplitude	V Clamp
EPSC_tau	Mean spontaneous EPSC decay constant	V Clamp	Least-squares exponential decay	N/A
S_freq_1	Spiking frequency: Lv. 1	I Clamp	Direct measurement	N/A
S_freq_2	Spiking frequency: Lv. 2	I Clamp	Direct measurement	N/A
S_freq_3	Spiking frequency: Lv. 3	I Clamp	Direct measurement	N/A
S_freq_4	Spiking frequency: Lv. 4	I Clamp	Direct measurement	N/A
S1_slope	Initial action potential rising slope	I Clamp	Initial spike derivative peak	Meeks et al., 2005
S1_thresh	Initial action potential threshold	I Clamp	Vm at 10% of initial spike derivative
S_accom_1	Spike rate accommodation: Lv. 1	I Clamp	$\frac{S_{\text{init}}-S_{\text{final}}}{S_{\text{init}}+S_{\text{final}}}$	N/A
S_accom_2	Spike rate accommodation: Lv. 2	I Clamp
S_accom_3	Spike rate accommodation: Lv. 3	I Clamp
S_accom_4	Spike rate accommodation: Lv. 4	I Clamp
Na_curr_1	Voltage-gated sodium current amplitude: Lv. 1	V Clamp	Direct measurement	N/A
Na_curr_2	Voltage-gated sodium current amplitude: Lv. 2	V Clamp	Direct measurement	N/A
Na_curr_3	Voltage-gated sodium current amplitude: Lv. 3	V Clamp	Direct measurement	N/A
Na_curr_4	Voltage-gated sodium current amplitude: Lv. 4	V Clamp	Direct measurement	N/A
Na_curr_5	Voltage-gated sodium current amplitude: Lv. 5	V Clamp	Direct measurement	N/A
K_curr_max	Voltage-gated potassium current: maximum	V Clamp	Direct measurement	N/A
K_curr_diff	Noninactivating voltage-gated potassium current	V Clamp	Direct measurement	N/A

N/A, Not applicable; Lv., level; V Clamp, voltage clamp; I Clamp, current clamp.