Table 1. Gene ontology analysis of DEGs.

Expression	Category	GO-ID	Term	Gene count	%	P value
Up-regulated	BP	GO:0050832	Defense response to fungus	11	5.6	9.20E-12
	BP	GO:0009620	Response to fungus	11	5.6	3.00E-10
	BP	GO:0050830	Defense response to Gram-positive bacterium	12	6.1	3.00E-09
	BP	GO:0042742	Defense response to bacterium	18	9.1	7.00E-09
	BP	GO:0009617	Response to bacterium	25	12.7	2.30E-08
	MF	GO:1901681	Sulfur compound binding	16	8.1	4.30E-08
	MF	GO:0005539	Glycosaminoglycan binding	15	7.6	6.20E-08
	MF	GO:0008201	Heparin binding	13	6.6	1.80E-07
	MF	GO:0050786	RAGE receptor binding	4	2	1.90E-04
	MF	GO:0016209	Antioxidant activity	7	3.6	1.90E-04
	CC	GO:0005615	Extracellular space	56	28.4	1.10E-15
	CC	GO:0044421	Extracellular region part	89	45.2	4.00E-12
	CC	GO:0005576	Extracellular region	96	48.7	9.00E-11
	CC	GO:0070062	Extracellular exosome	68	34.5	1.10E-09
	CC	GO:1903561	Extracellular vesicle	68	34.5	1.40E-09
Down-regulated	BP	GO:0030198	Extracellular matrix organization	37	11.6	3.00E-18
	BP	GO:0043062	Extracellular structure organization	37	11.6	3.30E-18
	BP	GO:0032963	Collagen metabolic process	20	6.3	1.30E-13
	BP	GO:0044259	Multicellular organismal macromolecule metabolic process	20	6.3	2.80E-13
	BP	GO:0044259	Multicellular organism metabolic process	20	6.3	3.90E-12
	MF	GO:0005201	Extracellular matrix structural constituent	16	5	1.20E-11
	MF	GO:0005198	Structural molecule activity	43	13.5	9.00E-11
	MF	GO:0019838	Growth factor binding	16	5	7.90E-09
	MF	GO:0030020	Extracellular matrix structural constituent conferring tensile strength	6	1.9	9.90E-09
	MF	GO:0005102	Receptor binding	49	15.4	2.00E-05
	CC	GO:0044421	Extracellular region part	159	50	1.10E-25
	CC	GO:0044421	Extracellular region	171	53.8	3.10E-23
	CC	GO:0031012	Extracellular matrix	53	16.7	3.40E-22
	CC	GO:0005578	Proteinaceous extracellular matrix	43	13.5	8.60E-21
	CC	GO:0005788	Endoplasmic reticulum lumen	29	9.1	2.50E-16

Abbreviations: BP, Biological process; MF, Molecular function; CC, Cellular component.