Table 1. Baseline characteristics of GBM patients from SEER, TCR and the combined dataset, by calendar period of diagnosis.
| Jan 2000-Feb 2005 (P1) | Mar 2005-Apr 2009 (P2) | May 2009-Dec 2013 (P3) | Total (P1, P2 and P3) | Pe | Pf | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SEER | TCR | Combined | Pa | SEER | TCR | Combined | Pb | SEER | TCR | Combined | Pc | SEER | TCR | Combined | Pd | |||
| Characteristics | N=8169 | N=1357 | N=9526 | N=7420 | N=1286 | N=8706 | N=8989 | N=1712 | N=10701 | N=24578 | N=4355 | N=28933 | ||||||
| Age at diagnosis, N (%) | ||||||||||||||||||
| 20-49 | 1660 (20.3) | 273 (20.1) | 1933 (20.3) | <0.001 | 1310 (17.7) | 238 (18.5) | 1548 (17.8) | 0.832 | 1409 (15.7) | 290 (16.9) | 1699 (15.9) | 0.231 | 4379 (17.8) | 801 (18.4) | 5180 (17.9) | 0.008 | <0.001 | 0.001 |
| 50-59 | 2004 (24.5) | 399 (29.4) | 2403 (25.2) | 2010 (27.1) | 341 (26.5) | 2351 (27.0) | 2270 (25.3) | 433 (25.3) | 2703 (25.3) | 6284 (25.6) | 1173 (26.9) | 7457 (25.8) | ||||||
| 60-69 | 2097 (25.7) | 359 (26.5) | 2456 (25.8) | 2091 (28.2) | 353 (27.5) | 2444 (28.1) | 2852 (31.7) | 558 (32.6) | 3410 (31.9) | 7040 (28.6) | 1270 (29.2) | 8310 (28.7) | ||||||
| 70- | 2408 (29.5) | 326 (24.0) | 2734 (28.7) | 2009 (27.1) | 354 (27.5) | 2363 (27.1) | 2458 (27.3) | 431 (25.2) | 2889 (27.0) | 6875 (28.0) | 1111 (25.5) | 7986 (27.6) | ||||||
| Sex, N (%) | ||||||||||||||||||
| Male | 4825 (59.1) | 818 (60.3) | 5643 (59.2) | 0.399 | 4388 (59.1) | 784 (61.0) | 5172 (59.4) | 0.218 | 5219 (58.1) | 1005 (58.7) | 6224 (58.2) | 0.621 | 14432 (58.7) | 2607 (59.9) | 17039 (58.9) | 0.158 | 0.279 | 0.426 |
| Female | 3344 (40.9) | 539 (39.7) | 3883 (40.8) | 3032 (40.9) | 502 (39.0) | 3534 (40.6) | 3770 (41.9) | 707 (41.3) | 4477 (41.8) | 10146 (41.3) | 1748 (40.1) | 11894 (41.1) | ||||||
| Race/Ethnicity, N (%) | ||||||||||||||||||
| White | 6735 (82.4) | 1074 (79.1) | 7809 (82.0) | <0.001 | 5957 (80.3) | 980 (76.2) | 6937 (79.7) | <0.001 | 7076 (78.7) | 1220 (71.3) | 8296 (77.5) | <0.001 | 19768 (80.4) | 3274 (75.2) | 23042 (79.6) | <0.001 | <0.001 | <0.001 |
| Black | 415 (5.1) | 72 (5.3) | 487 (5.1) | 394 (5.3) | 87 (6.8) | 481 (5.5) | 532 (5.9) | 110 (6.4) | 642 (6.0) | 1341 (5.5) | 269 (6.2) | 1610 (5.6) | ||||||
| Hispanic | 697 (8.5) | 196 (14.4) | 893 (9.4) | 747 (10.1) | 197 (15.3) | 944 (10.8) | 900 (10.0) | 322 (18.8) | 1222 (11.4) | 2344 (9.5) | 715 (16.4) | 3059 (10.6) | ||||||
| Others | 322 (3.9) | 15 (1.1) | 337 (3.5) | 322 (4.3) | 22 (1.7) | 344 (4.0) | 481 (5.4) | 60 (3.5) | 541 (5.1) | 1125 (4.6) | 97 (2.2) | 1222 (4.2) | ||||||
| Marital status, N (%) | ||||||||||||||||||
| Single | 953 (11.7) | 173 (12.8) | 1126 (11.8) | 0.021 | 963 (13.0) | 164 (12.8) | 1127 (12.9) | 0.119 | 1343 (14.9) | 272 (15.9) | 1615 (15.1) | 0.261 | 3259 (13.3) | 609 (14.0) | 3868 (13.4) | 0.001 | <0.001 | 0.068 |
| Married | 5582 (68.3) | 955 (70.4) | 6537 (68.6) | 5062 (68.2) | 910 (70.8) | 5972 (68.6) | 6027 (67.1) | 1157 (67.6) | 7184 (67.1) | 16671 (67.8) | 3022 (69.4) | 19693 (68.1) | ||||||
| DWS | 1634 (20.0) | 229 (16.9) | 1863 (19.6) | 1395 (18.8) | 212 (16.5) | 1607 (18.5) | 1619 (18.0) | 283 (16.5) | 1902 (17.8) | 4648 (18.9) | 724 (16.6) | 5372 (18.6) | ||||||
| Tumor site, N (%) | ||||||||||||||||||
| Supratentorial | 6137 (75.1) | 1072 (79.0) | 7209 (75.7) | 0.002 | 5832 (78.6) | 1023 (79.6) | 6855 (78.7) | 0.442 | 7036 (78.3) | 1328 (77.6) | 8364 (78.2) | 0.519 | 19005 (77.3) | 3423 (78.6) | 22428 (77.5) | 0.063 | <0.001 | 0.388 |
| Infratentorial/NOS | 2032 (24.9) | 285 (21.0) | 2317 (24.3) | 1588 (21.4) | 263 (20.5) | 1851 (21.3) | 1953 (21.7) | 384 (22.4) | 2337 (21.8) | 5573 (22.7) | 932 (21.4) | 6505 (22.5) | ||||||
| Surgery, N (%) | ||||||||||||||||||
| No surgery | 1683 (20.6) | 244 (18.0) | 1927 (20.2) | 0.001 | 1475 (19.9) | 216 (16.8) | 1691 (19.4) | 0.007 | 1438 (16.0) | 293 (17.1) | 1731 (16.2) | 0.021 | 4596 (18.7) | 753 (17.3) | 5349 (18.5) | <0.001 | <0.001 | 0.315 |
| Local excision/biopsy | 1499 (18.4) | 288 (21.2) | 1787 (18.8) | 1433 (19.3) | 260 (20.2) | 1693 (19.4) | 1940 (21.6) | 329 (19.2) | 2269 (21.2) | 4872 (19.8) | 877 (20.1) | 5749 (19.9) | ||||||
| Partial resection | 2320 (28.4) | 344 (25.4) | 2664 (28.0) | 2035 (27.4) | 330 (25.7) | 2365 (27.2) | 2718 (30.2) | 490 (28.6) | 3208 (30.0) | 7073 (28.8) | 1164 (26.7) | 8237 (28.5) | ||||||
| GTR | 2667 (32.7) | 481 (35.5) | 3148 (33.0) | 2477 (33.4) | 480 (37.3) | 2957 (34.0) | 2893 (32.2) | 600 (35.1) | 3493 (32.6) | 8037 (32.7) | 1561 (35.8) | 9598 (33.2) | ||||||
| Radiation, N (%) | ||||||||||||||||||
| Untreated | 1659 (20.3) | 261 (19.2) | 1920 (20.2) | 0.361 | 1425 (19.2) | 388 (30.2) | 1813 (20.8) | <0.001 | 1565 (17.4) | 683 (39.9) | 2248 (21.0) | <0.001 | 4649 (18.9) | 1332 (30.6) | 5981 (20.7) | <0.001 | <0.001 | <0.001 |
| Treated | 6510 (79.7) | 1096 (80.8) | 7606 (79.8) | 5995 (80.8) | 898 (69.8) | 6893 (79.2) | 7424 (82.6) | 1029 (60.1) | 8453 (79.0) | 19929 (81.1) | 3023 (69.4) | 22952 (79.3) | ||||||
Abbreviation: DWS, divorced or widowed or separated; NOS, not otherwise specified; GTR, gross total resection.
a, b, c and d: Pearson's χ2 test was conducted to compare the proportions of baseline characteristics between SEER and TCR within P1, P2 and P3, respectively.
e and f: Pearson's χ2 test was conducted to compare the proportions of baseline characteristics across calendar period of diagnosis in SEER and TCR respectively.