Table 3. Risk of death among GBM patients in relation to calendar period of diagnosis in SEER (N=24578).
| Cases | Death | Age-sex adjusted | Model 1a | Model 2b | Model 3c | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Predictors | N | N | HR | 95%CI | HR | 95%CI | HR | 95%CI | HR | 95%CI |
| Calendar period of diagnosis | ||||||||||
| Jan 2000-Feb 2005 (P1) | 8169 | 7960 | 1.00 | - | 1.00 | - | 1.00 | - | 1.00 | - |
| Mar 2005-Apr 2009 (P2) | 7420 | 7045 | 0.82 | 0.79 - 0.85 | 0.82 | 0.79 - 0.85 | 0.83 | 0.80 - 0.85 | 0.83 | 0.81 - 0.86 |
| May 2009-Dec 2013 (P3) | 8989 | 6359 | 0.74 | 0.72 - 0.76 | 0.74 | 0.72 - 0.77 | 0.75 | 0.72 - 0.77 | 0.77 | 0.74 - 0.79 |
| Age at diagnosis group | ||||||||||
| 20-49 | 4379 | 3401 | 1.00 | - | 1.00 | - | 1.00 | - | 1.00 | - |
| 50-59 | 6284 | 5321 | 1.50 | 1.44 - 1.57 | 1.51 | 1.44 - 1.58 | 1.50 | 1.44 - 1.57 | 1.50 | 1.44 - 1.57 |
| 60-69 | 7040 | 6186 | 2.02 | 1.94 - 2.11 | 2.03 | 1.94 - 2.12 | 2.03 | 1.95 - 2.12 | 2.00 | 1.92 - 2.09 |
| 70- | 6875 | 6456 | 3.41 | 3.27 - 3.56 | 3.39 | 3.24 - 3.54 | 3.39 | 3.24 - 3.54 | 3.12 | 2.98 - 3.26 |
| Sex | ||||||||||
| Male | 14432 | 12531 | 1.00 | - | 1.00 | - | 1.00 | - | 1.00 | - |
| Female | 10146 | 8833 | 0.97 | 0.94 - 0.99 | 0.94 | 0.91 - 0.96 | 0.94 | 0.91 - 0.96 | 0.94 | 0.92 - 0.97 |
| Race/Ethnicity | ||||||||||
| White | 19768 | 17399 | 1.00 | - | 1.00 | - | 1.00 | - | ||
| Black | 1341 | 1134 | 1.06 | 1.00 - 1.13 | 1.06 | 0.99 - 1.12 | 1.02 | 0.96 - 1.08 | ||
| Hispanic | 2344 | 1938 | 0.98 | 0.93 - 1.02 | 0.97 | 0.92 - 1.02 | 0.94 | 0.89 - 0.98 | ||
| Others | 1125 | 893 | 0.83 | 0.78 - 0.89 | 0.82 | 0.77 - 0.88 | 0.80 | 0.75 - 0.86 | ||
| Marital status | ||||||||||
| Single | 3259 | 2667 | 1.00 | - | 1.00 | - | 1.00 | - | ||
| Married | 16671 | 14468 | 0.90 | 0.86 - 0.93 | 0.89 | 0.86 - 0.93 | 0.95 | 0.91 - 0.99 | ||
| DWS | 4648 | 4229 | 1.09 | 1.04 - 1.15 | 1.09 | 1.04 - 1.15 | 1.11 | 1.06 - 1.17 | ||
| Tumor site | ||||||||||
| Supratentorial | 19005 | 16380 | 1.00 | - | 1.00 | - | ||||
| Infratentorial/NOS | 5573 | 4984 | 1.24 | 1.20 - 1.28 | 1.15 | 1.11 - 1.18 | ||||
| Surgery | ||||||||||
| No surgery | 4596 | 4332 | 1.00 | - | ||||||
| Local excision/biopsy | 4872 | 4295 | 0.61 | 0.58 - 0.63 | ||||||
| Partial resection | 7073 | 6111 | 0.65 | 0.63 - 0.68 | ||||||
| GTR | 8037 | 6626 | 0.49 | 0.47 - 0.51 | ||||||
| Radiation | ||||||||||
| Untreated | 4649 | 4386 | 1.00 | - | ||||||
| Treated | 19929 | 16978 | 0.51 | 0.49 - 0.52 | ||||||
Abbreviation: DWS, divorced or widowed or separated; NOS, not otherwise specified; GTR, gross total resection; HR, hazard ratio; 95%CI, 95% confidence interval.
a: Model 1: Adjusted age at diagnosis, sex, race/ethnicity and marital status.
b: Model 2: Adjusted age at diagnosis, sex, race/ethnicity, marital status and tumor site.
c: Model 3: Adjusted age at diagnosis, sex, race/ethnicity, marital status, tumor site, surgery and radiation.