Table 4. Risk of death among GBM patients in relation to calendar period of diagnosis in TCR (N=4355).
| Cases | Death | Age-sex adjusted | Model 1a | Model 2b | Model 3c | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Predictors | N | N | HR | 95%CI | HR | 95%CI | HR | 95%CI | HR | 95%CI |
| Calendar period of diagnosis | ||||||||||
| Jan 2000-Feb 2005 (P1) | 1357 | 1318 | 1.00 | - | 1.00 | - | 1.00 | - | 1.00 | - |
| Mar 2005-Apr 2009 (P2) | 1286 | 1219 | 0.81 | 0.75 - 0.88 | 0.81 | 0.75 - 0.88 | 0.81 | 0.75 - 0.88 | 0.79 | 0.73 - 0.86 |
| May 2009-Dec 2013 (P3) | 1712 | 1242 | 0.83 | 0.76 - 0.89 | 0.83 | 0.77 - 0.90 | 0.83 | 0.77 - 0.90 | 0.78 | 0.72 - 0.84 |
| Age at diagnosis group | ||||||||||
| 20-49 | 801 | 621 | 1.00 | - | 1.00 | - | 1.00 | - | 1.00 | - |
| 50-59 | 1173 | 996 | 1.46 | 1.32 - 1.62 | 1.45 | 1.31 - 1.60 | 1.44 | 1.30 - 1.60 | 1.41 | 1.28 - 1.56 |
| 60-69 | 1270 | 1115 | 1.93 | 1.75 - 2.13 | 1.91 | 1.73 - 2.11 | 1.91 | 1.72 - 2.11 | 1.86 | 1.68 - 2.06 |
| 70- | 1111 | 1047 | 3.18 | 2.88 - 3.53 | 3.12 | 2.81 - 3.46 | 3.13 | 2.82 - 3.48 | 2.88 | 2.59 - 3.20 |
| Sex | ||||||||||
| Male | 2607 | 2257 | 1.00 | - | 1.00 | - | 1.00 | - | 1.00 | - |
| Female | 1748 | 1522 | 1.02 | 0.95 - 1.08 | 1.00 | 0.93 - 1.07 | 1.00 | 0.94 - 1.07 | 0.99 | 0.92 - 1.05 |
| Race/Ethnicity | ||||||||||
| White | 3274 | 2902 | 1.00 | - | 1.00 | - | 1.00 | - | ||
| Black | 269 | 232 | 1.05 | 0.92 - 1.20 | 1.04 | 0.91 - 1.19 | 1 | 0.87 - 1.14 | ||
| Hispanic | 715 | 577 | 0.91 | 0.83 - 1.00 | 0.89 | 0.82 - 0.98 | 0.86 | 0.79 - 0.94 | ||
| Others | 97 | 68 | 0.74 | 0.58 - 0.94 | 0.73 | 0.57 - 0.93 | 0.68 | 0.54 - 0.87 | ||
| Marital status | ||||||||||
| Single | 609 | 494 | 1.00 | - | 1.00 | - | 1.00 | - | ||
| Married | 3022 | 2639 | 0.97 | 0.88 - 1.07 | 0.98 | 0.89 - 1.08 | 1.03 | 0.94 - 1.14 | ||
| DWS | 724 | 646 | 1.10 | 0.98 - 1.25 | 1.12 | 0.99 - 1.26 | 1.16 | 1.03 - 1.31 | ||
| Tumor site | ||||||||||
| Supratentorial | 3423 | 2961 | 1.00 | - | 1.00 | - | ||||
| Infratentorial/NOS | 932 | 818 | 1.25 | 1.16 - 1.35 | 1.15 | 1.06 - 1.24 | ||||
| Surgery | ||||||||||
| No surgery | 753 | 686 | 1.00 | - | ||||||
| Local excision/biopsy | 877 | 782 | 0.65 | 0.59 - 0.73 | ||||||
| Partial resection | 1164 | 1005 | 0.73 | 0.66 - 0.80 | ||||||
| GTR | 1561 | 1306 | 0.56 | 0.51 - 0.61 | ||||||
| Radiation | ||||||||||
| Untreated | 1332 | 1157 | 1.00 | - | ||||||
| Treated | 3023 | 2622 | 0.71 | 0.66 - 0.77 | ||||||
Abbreviation: DWS, divorced or widowed or separated; NOS, not otherwise specified; GTR, gross total resection; HR, hazard ratio; 95%CI, 95% confidence interval.
a: Model 1: Adjusted age at diagnosis, sex, race/ethnicity and marital status.
b: Model 2: Adjusted age at diagnosis, sex, race/ethnicity, marital status and tumor site.
c: Model 3: Adjusted age at diagnosis, sex, race/ethnicity, marital status, tumor site, surgery and radiation.