Table 6. Risk of death in GBM patients by calendar period of diagnosis and by time-varying covariates*.
| SEER | TCR | The combined dataset | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P1 | P2 | P3 | P1 | P2 | P3 | P1 | P2 | P3 | ||||||||||
| Time-varying covariates | HR | 95%CI | HR | 95%CI | HR | 95%CI | HR | 95%CI | HR | 95%CI | HR | 95%CI | HR | 95%CI | HR | 95%CI | HR | 95%CI |
| Age group at diagnosis | ||||||||||||||||||
| 20-49 | 1.00 | - | 0.87 | 0.81 - 0.94 | 0.73 | 0.67 - 0.80 | 1.00 | - | 0.86 | 0.71 - 1.04 | 0.76 | 0.61 - 0.94 | 1.00 | - | 0.87 | 0.81 - 0.94 | 0.73 | 0.68 - 0.80 |
| 50-59 | 1.00 | - | 0.82 | 0.77 - 0.87 | 0.73 | 0.68 - 0.78 | 1.00 | - | 0.80 | 0.69 - 0.93 | 0.68 | 0.58 - 0.79 | 1.00 | - | 0.81 | 0.76 - 0.85 | 0.71 | 0.66 - 0.75 |
| 60-69 | 1.00 | - | 0.80 | 0.75 - 0.85 | 0.74 | 0.70 - 0.79 | 1.00 | - | 0.82 | 0.70 - 0.95 | 0.77 | 0.66 - 0.89 | 1.00 | - | 0.80 | 0.75 - 0.84 | 0.74 | 0.70 - 0.78 |
| 70- | 1.00 | - | 0.89 | 0.84 - 0.95 | 0.85 | 0.80 - 0.90 | 1.00 | - | 0.78 | 0.67 - 0.91 | 0.91 | 0.78 - 1.06 | 1.00 | - | 0.87 | 0.82 - 0.92 | 0.85 | 0.80 - 0.89 |
| Tumor site | ||||||||||||||||||
| Supratentorial | 1.00 | - | 0.83 | 0.80 - 0.86 | 0.77 | 0.74 - 0.80 | 1.00 | - | 0.76 | 0.70 - 0.83 | 0.75 | 0.68 - 0.82 | 1.00 | - | 0.81 | 0.79 - 0.84 | 0.75 | 0.73 - 0.78 |
| Infratentorial/NOS | 1.00 | - | 0.84 | 0.78 - 0.90 | 0.76 | 0.71 - 0.81 | 1.00 | - | 0.78 | 0.31 - 1.95 | 0.74 | 0.30 - 1.81 | 1.00 | - | 0.78 | 0.57 - 1.06 | 0.76 | 0.55 - 1.04 |
| Surgery | ||||||||||||||||||
| No surgery | 1.00 | - | 0.89 | 0.83 - 0.95 | 0.84 | 0.78 - 0.91 | 1.00 | - | 0.90 | 0.74 - 1.08 | 0.95 | 0.79 - 1.15 | 1.00 | - | 0.89 | 0.84 - 0.95 | 0.83 | 0.77 - 0.88 |
| Local excision/biopsy | 1.00 | - | 0.90 | 0.83 - 0.97 | 0.92 | 0.86 - 0.99 | 1.00 | - | 0.77 | 0.64 - 0.92 | 0.72 | 0.60 - 0.86 | 1.00 | - | 0.85 | 0.79 - 0.91 | 0.83 | 0.78 - 0.89 |
| Partial resection | 1.00 | - | 0.79 | 0.74 - 0.84 | 0.74 | 0.69 - 0.78 | 1.00 | - | 0.80 | 0.68 - 0.93 | 0.70 | 0.60 - 0.82 | 1.00 | - | 0.77 | 0.73 - 0.82 | 0.70 | 0.66 - 0.74 |
| GTR | 1.00 | - | 0.89 | 0.84 - 0.94 | 0.80 | 0.75 - 0.85 | 1.00 | - | 0.77 | 0.68 - 0.88 | 0.78 | 0.68 - 0.89 | 1.00 | - | 0.82 | 0.78 - 0.86 | 0.73 | 0.69 - 0.77 |
| Radiation | ||||||||||||||||||
| Untreated | 1.00 | - | 0.97 | 0.90 - 1.04 | 0.93 | 0.86 - 1.00 | 1.00 | - | 0.85 | 0.72 - 1.00 | 0.76 | 0.65 - 0.88 | 1.00 | - | 0.96 | 0.90 - 1.02 | 0.90 | 0.84 - 0.96 |
| Treated | 1.00 | - | 0.79 | 0.76 - 0.82 | 0.72 | 0.69 - 0.75 | 1.00 | - | 0.78 | 0.71 - 0.85 | 0.81 | 0.73 - 0.89 | 1.00 | - | 0.79 | 0.77 - 0.82 | 0.73 | 0.71 - 0.76 |
Abbreviation: Calendar period of diagnosis, including P1, P2 and P3 (P1, Jan 2000-Feb 2005; P2, Mar 2005-Apr 2009; P3, May 2009-Dec 2013); NOS, not otherwise specified; GTR, gross total resection; HR, hazard ratio; 95%CI, 95% confidence interval.
*: Adjusted age at diagnosis, sex, race/ethnicity, marital status, tumor site, surgery, radiation and cancer registries as appropriate.