Table 2. Dose-escalation strategy.

DoseLevel	Irinotecan	Cisplatin	Olaparib	Mitomycin C
−1	Irinotecan 70 mg/m2 on days 1 and 8	Cisplatin 25 mg/m2 on days 1 and 8	50mg twice a day on days 1 and 8	None
1	Irinotecan 70 mg/m2 on days 1 and 8	Cisplatin 25 mg/m2 on days 1 and 8	100 mg twice a day on days 1 and 8	None
2	Irinotecan 70 mg/m2 on days 1 and 8	Cisplatin 25 mg/m2 on days 1 and 8	100mg twice a day on days 1–3, 8–10	None
3	Irinotecan 70 mg/m2 on days 1 and 8	Cisplatin 25 mg/m2 on days 1 and 8	200 mg twice a day on days 1–3, 8–10	None
4	Irinotecan 70 mg/m2 on days 1 and 8	Cisplatin 25 mg/m2 on days 1 and 8	200 mg twice a day on days 1–12	None
5	Irinotecan 70 mg/m2 on days 1 and 8	Cisplatin 25 mg/m2 on days 1 and 8	MTD from dose level escalation (−1 to 4)	5 mg/m2 on day 1

Treatment days are in reference to a 28-day treatment cycle