Table 2. Expression and diagnostic value of specific circRNAs in breast cancer.

CircRNAs	Expressiona		t	P	AUC (95% CI)	Sensitivity (95% CI)	Specificity (95% CI)	Cut-off valueb
	Breast cancer	Adjacent tissues
hsa_circ_103110	8.79±1.86	9.62±1.63	2.49	0.016	0.63 (0.52–0.74)	0.63 (0.48–0.76)	0.63 (0.48–0.76)	8.97
hsa_circ_104689	7.66±1.48	8.31±1.57	2.09	0.041	0.61 (0.50–0.73)	0.57 (0.42–0.71)	0.55 (0.40–0.69)	7.67
hsa_circ_104821	6.07±1.55	6.52±1.68	2.22	0.031	0.60 (0.49–0.71)	0.57 (0.42–0.71)	0.57 (0.42–0.71)	6.04
hsa_circ_006054	15.66±1.82	14.29±1.75	4.30	<0.001c	0.71 (0.61–0.81)	0.65 (0.50–0.78)	0.69 (0.54–0.81)	14.84
hsa_circ_100219	10.13±1.58	8.53±1.43	5.70	<0.001c	0.78 (0.69–0.88)	0.69 (0.54–0.81)	0.71 (0.56–0.83)	8.95
hsa_circ_406697	14.85±2.27	13.96±1.68	2.76	0.008c	0.64 (0.52–0.75)	0.63 (0.48–0.76)	0.63 (0.48–0.76)	14.24

^a: The expression of each circRNA was calculated from the ΔCt and expressed as mean±standard deviation; ^b: We used the median as the cut-off value; ^c: Significant after Bonferroni correction (P<0.008); AUC: area under the curve; CI: confidence interval.