Table 4. Relation between cumulative defined daily dose of digoxin per year and HF patients with cancers.
| Dose | No. of Cases | PY | Incidencea | CHR (95% C.I.) | AHR (95% C.I.) |
|---|---|---|---|---|---|
| ALL | |||||
| DDD<140 | 93 | 5058.4 | 1.84 | Ref. | Ref. |
| DDD≥140 | 106 | 5394.9 | 1.96 | 1.06 (0.80–1.40) | 1.12 (0.85–1.49) |
| Age<45 | |||||
| DDD<140 | 3 | 292.9 | 1.02 | Ref. | Ref. |
| DDD≥140 | 2 | 396.5 | 0.50 | 0.51 (0.08–3.02) | 0.21 (0.02–2.87) |
| 45≤Age<65 | |||||
| DDD<140 | 23 | 1571 | 1.46 | Ref. | Ref. |
| DDD≥140 | 23 | 1599 | 1.44 | 0.98 (0.55–1.74) | 1.05 (0.59–1.89) |
| Age ≥65 | |||||
| DDD<140 | 67 | 3194.5 | 2.10 | Ref. | Ref. |
| DDD≥140 | 81 | 3399.4 | 2.38 | 1.12 (0.81–1.55) | 1.17 (0.84–1.63) |
| Female | |||||
| DDD<140 | 47 | 2679.9 | 1.75 | Ref. | Ref. |
| DDD≥140 | 63 | 2905.7 | 2.17 | 1.24 (0.85–1.81) | 1.32 (0.90–1.93) |
| Male | |||||
| DDD<140 | 46 | 2378.5 | 1.93 | Ref. | Ref. |
| DDD≥140 | 43 | 2489.2 | 1.73 | 0.88 (0.58–1.33) | 0.93 (0.61–1.42) |
| CCI <3 | |||||
| DDD<140 | 12 | 1222.3 | 0.98 | Ref. | Ref. |
| DDD≥140 | 24 | 1840.7 | 1.30 | 1.34 (0.67–2.67) | 1.25 (0.62–2.53) |
| CCI ≥3 | |||||
| DDD<140 | 81 | 3836.1 | 2.11 | Ref. | Ref. |
| DDD≥140 | 82 | 3554.2 | 2.31 | 1.09 (0.80–1.48) | 1.08 (0.79–1.48) |
CHR: Crude hazard ratio, The median of cumulative per year dose: 140, HF, Heart Failure
AHR (adjusted hazard ratio): Controlling the variables of age, gender, income, region, urbanization, cci *: p<0.05 **: p<0.001
a: person-years at risk per 100 person-years
DDD, defined daily dose