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. 2017 Apr 25;8(27):44203–44216. doi: 10.18632/oncotarget.17410

Table 5. Incidence and CHR, AHR for cancer among the sampled patients, according to cancer type, during 8-year followed up period.

Presence of cancer Total(n=4,161) HF with Digoxin(n=1,219) HF with Non-Digoxin(n=2,942)
Lung Cancer (n,%) 125, 3.00% 42, 3.45% 83, 2.82%
 Incidence per 100 person-years 1.54 1.75 1.46
 CHRa (95% CI) 1.38(1.11–1.7)* 1.00
 AHRb (95% CI) 1.21(0.98–1.50) 1.00
Breast Cancer (n,%) 30, 0.72% 8, 0.66% 22, 0.75%
 Incidence per 100 person-years 1.43 1.44 1.43
 CHRa (95% CI) 1.47(1.18–1.83)** 1.00
 AHRb (95% CI) 1.30(1.05–1.62)* 1.00
Liver Cancer (n,%) 97, 2.33% 34, 2.79% 63, 2.14%
 Incidence per 100 person-years 1.49 1.61 1.42
 CHRa (95% CI) 1.46(1.17–1.83)** 1.00
 AHRb (95% CI) 1.29(1.03–1.62)* 1.00
Colorectal Cancer (n,%) 149, 3.58% 43, 3.53% 106, 3.60%
 Incidence per 100 person-years 1.57 1.67 1.54
 CHRa (95% CI) 1.13(0.80–1.62) 1.00
 AHRb (95% CI) 1.01(0.70–1.44) 1.00
Prostate Cancer (n,%) 59, 1.42% 14, 1.15% 45, 1.53%
 Incidence per 100 person-years 1.63 1.55 1.66
 CHRa (95% CI) 0.85(0.47–1.55) 1.00
 AHRb (95% CI) 0.75(0.41–1.37) 1.00
Gynecology Cancer (n,%) 34, 0.82% 14, 1.15% 20,0.68%
 Incidence per 100 person-years 1.85 2.26 1.65
 CHRa (95% CI) 1.87(0.94–3.70) 1.00
 AHRb (95% CI) 2.01(1.02–4.20) 1.00
Bladder Cancer (n,%) 32, 0.77% 8, 0.66% 24, 0.82%
 Incidence per 100 person-years 1.48 1.65 1.44
 CHRa (95% CI) 0.95(0.42–2.11) 1.00
 AHRb (95% CI) 0.82(0.37–1.84) 1.00
Kidney Cancer (n,%) 30, 0.72% 5, 0.41% 25, 0.85%
 Incidence per 100 person-years 1.52 1.87 1.46
 CHRa (95% CI) 0.55(0.21–1.45) 1.00
 AHRb (95% CI) 0.47(0.18–1.24) 1.00
Oral Cancer (n,%) 18, 0.43% 5, 0.41% 13, 0.44%
 Incidence per 100 person-years 1.39 1.33 1.42
 CHRa (95% CI) 1.13(0.40–3.18) 1.00
 AHRb (95% CI) 1.12(0.39–3.18) 1.00
Other Cancer (n,%) 672, 16.15% 195, 16.00% 477, 16.21%
 Incidence per 100 person-years 1.62 1.78 1.56
 CHRa (95% CI) 1.14(0.96–1.35) 1.00
 AHRb (95% CI) 1.03(0.87–1.21) 1.00

aCHR: Crude hazard ratio was calculated by using stratified Cox proportional hazards regression, HF: Heart Failure

b.AHR (adjusted hazard ratio): Controlling the variables of age, gender, income, region, urbanization, cci, *: p<0.05 **: p<0.001

ICD-9-code: Prostate Cancer:185 Liver Cancer:155 Gynecology Cancer:180.182.183 Breast Cancer:174 Lung Cancer:162 Colorectal Cancer:153.154 Oral Cancer:145.141 Bladder Cancer:188 Kidney Cancer:189 Gall bladder Cancer:156