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. 2017 Apr 27;8(27):44281–44294. doi: 10.18632/oncotarget.17471

Figure 6. Apicidin-induced YAP downregulation in MSC.

Figure 6

(A) YAP mRNA was significantly downregulated in 3 μM AC/MSC (n=6). (B) Immunofluorescence staining showed YAP protein downregulation by apicidin treatment. (C) Western blot was performed to validate the YAP protein expression over time course and showed YAP expression gradually decreased between 8h and 24h. (D) Knockdown of YAP by RNA interference increased mRNA levels of GATA4, Nkx2.5, and cTnI (n=4). (E) Diagram showing apicidin-induced YAP downregulation resulting in the induction of cardiac markers. *P<0.05; Scale bar=50 μm.