Figure 5. VDRM2 reduces tumor growth in a VCaP xenograft model.
(A) Tumor measurements were taken using digital calipers once per week starting on Day 22 when the tumors were palpable for measuring. n = 9 vehicle, n = 9 VDRM2. (B) At the end of the study mice were euthanized and tumors were removed and weighed using a digital balance. n = 9 vehicle, n = 9 VDRM2. (C) Images of the tumors harvested from vehicle-treated mice. (D) Images of the tumors harvested from VDRM2-treated mice. (E) Mice were weighed at the start and end of the study and weights plotted. n = 10 vehicle, n = 8 VDRM2. (F) Under deep anesthesia mice were exsanguinated via cardiac puncture and serum was separated from the blood. Serum samples were sent to the Baylor College of Medicine Pathology Core for serum calcium analysis. n = 10 vehicle, n = 8 VDRM2. .**p < 0.01, ***p < 0.001, mean ± SEM.