Table 1. Comparison among three subgroups of demographic, behavior and CSF data.
| ε2 carriers | ε4 carriers | Controls | F/χ2 | P | |
|---|---|---|---|---|---|
| Number | 20 | 41 | 74 | ||
| Demographic characteristics | |||||
| Age, y, mean (SD) | 73.57±5.21 | 73.33±7.11 | 74.26±6.12 | 0.31 | 0.73 |
| Female, n(%) | 10 (50.0%) | 20 (48.8%) | 34 (45.9%) | 0.15 | 0.93 |
| Education, y, mean (SD) | 16.85±2.50 | 16.20±2.40 | 16.80±2.41 | 0.92 | 0.40 |
| Vascular risk factors, n(%) | |||||
| Hypertension | 11 (55.0%) | 19 (46.3%) | 36 (48.6%) | 0.41 | 0.82 |
| Smoking history | 14 (70.0%) | 30 (73.2%) | 59 (79.7%) | 1.14 | 0.57 |
| Diabetes | 19 (95.0%) | 39 (95.1%) | 67 (90.5%) | 1.01 | 0.61 |
| Hachinski Ischemic Score | 0.75±0.91 | 0.46±0.50 | 0.55±0.64 | 1.30 | 0.28 |
| CSF biomarker | |||||
| Amyloid1–42 (ng/L) | 223.57±50.34 | 171.33±55.50 | 204.68±47.47 | 7.08 | <0.001 |
| T-tau (ng/L) | 55.64±22.13 | 71.25±31.16 | 71.25±40.16 | 1.56 | 0.22 |
| P-tau181 (ng/L) | 34.16±16.05 | 36.71±15.93 | 36.22±26.10 | 0.07 | 0.93 |
| Cognitive scores | |||||
| MMSE_baseline | 28.70±1.38 | 28.90±1.28 | 29.31±1.02 | 3.00 | 0.05 |
| MMSE_1 year follow-up | 29.20±1.01 | 28.73±1.55 | 28.80±1.25 | 0.92 | 0.40 |
| MMSE_2 year follow-up | 29.05±1.05 | 28.63±1.85 | 28.95±1.32 | 0.77 | 0.47 |
MMSE: Mini-Mental State Examination; *represent P < 0.05
It should be noted that mean level of Aβ1-42, t-tau and p-tau181 levels in Table 1 only represent the subjects who had CSF sample.