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. 2017 May 11;8(27):44498–44510. doi: 10.18632/oncotarget.17806

Figure 4. Effect of HIF-1α gene silencing on protein and mRNA expression and RhoA activation.

Figure 4

(A) HIF-1α protein expression in HIF-1α-silenced HT168-M1 cell lines. N: normoxic, H: hypoxic (1% O2) conditions. (B-C) Relative mRNA expression under hypoxic conditions compared to normoxic scramble-transfected human tumor cells (normoxic values=1, representative figures). (D-E) RhoA activation in control, scramble-treated and HIF-1α silenced tumor cells under hypoxic (1% O2) conditions. Data are mean ± SD, n=3, *p<0.05.