Table 2. Factors associated with cause-specific hazard of recurrence and ICC-related death according to multivariate Cox's Proportional Hazards Model.
| Variable | Tumor recurrence | Survival | ||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| CEA, μg/L, > 10 vs. ≤ 10 | 1.794 (1.166 – 2.761) | 0.008 | 1.812 (1.180 – 2.784) | 0.007 |
| CA 19–9, U/L, > 39 vs. ≤ 39 | 1.641 (1.218 – 2.213) | 0.001 | 1.711 (1.261 – 2.322) | 0.001 |
| Tumor diameter, cm, > 5 vs. ≤ 5 | 1.445 (1.080 – 1.933) | 0.013 | 1.369 (1.011 – 1.853) | 0.042 |
| Tumor number, Multiple vs. Solitary | 1.464 (1.089 – 1.968) | 0.011 | 1.614 (1.183 – 2.203) | 0.003 |
| Vascular invasion, Yes vs. No | 1.944 (1.317 – 2.868) | 0.001 | 1.847 (1.246 – 2.739) | 0.002 |
| Nodal metastasis, Yes vs. No | 2.034 (1.376 – 3.008) | <0.001 | 2.302 (1.552 – 3.413) | <0.001 |
| Local extrahepatic invasion,Yes vs. No | 1.933 (1.159 – 3.223) | 0.012 | 2.284 (1.349 – 3.869) | 0.002 |
Abbreviations: CEA, carcinoembryonic antigen; CA19-9, carbonhydrate antigen 19-9; HR, hazard ratio; CI, confidence interval.