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. 2017 Mar 15;8(27):44761–44775. doi: 10.18632/oncotarget.16226

Table 2. Overall analysis between hOGG1 Ser326Cys polymorphism and risk of cancer in Asian.

Cancers Comparison Heterogeneity Model OR (95% CI) p
p I-squared
All cancers C vs. G <0.001 44.278 Random 1.095 (1.048-1.145) <0.001
CC vs. CG+GG <0.001 48.900 Random 1.096 (1.015-1.183) 0.019
CC+CG vs. GG <0.001 63.487 Random 1.171 (1.070-1.282) 0.001
Colorectal cancer C vs. G 0.149 47.481 Fixed 0.987 (0.879-1.108) 0.822
CC vs. CG+GG 0.123 <0.001 Fixed 1.068 (0.868-1.315) 0.532
CC+CG vs. GG 0.451 <0.001 Fixed 0.945 (0.795-1.122) 0.517
Lung cancer C vs. G 0.487 <0.001 Fixed 1.110 (1.048-1.176) <0.001
CC vs. CG+GG 0.163 27.193 Fixed 1.116 (1.013-1.229) 0.027
CC+CG vs. GG 0.220 21.505 Fixed 1.176 (1.074-1.289) 0.000
Breast cancer C vs. G 0.376 6.340 Fixed 1.085 (1.013-1.162) 0.019
CC vs. CG+GG 0.942 <0.001 Fixed 1.098 (0.971-1.241) 0.135
CC+CG vs. GG 0.108 44.685 Fixed 1.122 (1.014-1.242) 0.026
Bladder cancer C vs. G 0.018 75.198 Random 1.135 (0.821-1.571) 0.444
CC vs. CG+GG 0.848 <0.001 Fixed 1.157 (0.910-1.472) 0.235
CC+CG vs. GG <0.001 89.184 Random 1.264 (0.503-3.174) 0.619
Gallbladder cancer C vs. G 0.015 83.061 Random 1.108 (0.710-1.728) 0.652
CC vs. CG+GG 0.029 78.918 Random 1.080 (0.644-1.812) 0.771
CC+CG vs. GG 0.074 68.567 Fixed 1.099 (0.761-1.585) 0.615
Gastric cancer C vs. G 0.075 49.976 Fixed 1.010 (0.904-1.129) 0.855
CC vs. CG+GG 0.561 <0.001 Fixed 0.977 (0.811-1.176) 0.802
CC+CG vs. GG 0.012 65.907 Random 1.232 (0.823-1.843) 0.311
Esophageal cancer C vs. G 0.837 <0.001 Fixed 1.087 (0.980-1.205) 0.113
CC vs. CG+GG 0.733 <0.001 Fixed 1.017 (0.875-1.182) 0.821
CC+CG vs. GG 0.031 56.757 Random 1.277 (0.939-1.735) 0.119
Head and neck cancer C vs. G 0.020 81.661 Random 1.499 (0.729-3.084) 0.271
CC vs. CG+GG 0.274 16.259 Fixed 1.856 (1.262-2.731) 0.002
CC+CG vs. GG 0.124 57.636 Fixed 0.964 (0.696-1.335) 0.825
Hepatocellular cancer C vs. G 0.001 74.985 Random 1.089 (0.883-1.344) 0.424
CC vs. CG+GG <0.001 89.658 Random 1.113 (0.673-1.841) 0.677
CC+CG vs. GG <0.001 85.472 Random 1.126 (0.723-1.754) 0.600

OR odds ratio, vs versus. Bold numbers indicate significant association with risk of cancer.