Table 2. Overall analysis between hOGG1 Ser326Cys polymorphism and risk of cancer in Asian.
Cancers | Comparison | Heterogeneity | Model | OR (95% CI) | p | |
---|---|---|---|---|---|---|
p | I-squared | |||||
All cancers | C vs. G | <0.001 | 44.278 | Random | 1.095 (1.048-1.145) | <0.001 |
CC vs. CG+GG | <0.001 | 48.900 | Random | 1.096 (1.015-1.183) | 0.019 | |
CC+CG vs. GG | <0.001 | 63.487 | Random | 1.171 (1.070-1.282) | 0.001 | |
Colorectal cancer | C vs. G | 0.149 | 47.481 | Fixed | 0.987 (0.879-1.108) | 0.822 |
CC vs. CG+GG | 0.123 | <0.001 | Fixed | 1.068 (0.868-1.315) | 0.532 | |
CC+CG vs. GG | 0.451 | <0.001 | Fixed | 0.945 (0.795-1.122) | 0.517 | |
Lung cancer | C vs. G | 0.487 | <0.001 | Fixed | 1.110 (1.048-1.176) | <0.001 |
CC vs. CG+GG | 0.163 | 27.193 | Fixed | 1.116 (1.013-1.229) | 0.027 | |
CC+CG vs. GG | 0.220 | 21.505 | Fixed | 1.176 (1.074-1.289) | 0.000 | |
Breast cancer | C vs. G | 0.376 | 6.340 | Fixed | 1.085 (1.013-1.162) | 0.019 |
CC vs. CG+GG | 0.942 | <0.001 | Fixed | 1.098 (0.971-1.241) | 0.135 | |
CC+CG vs. GG | 0.108 | 44.685 | Fixed | 1.122 (1.014-1.242) | 0.026 | |
Bladder cancer | C vs. G | 0.018 | 75.198 | Random | 1.135 (0.821-1.571) | 0.444 |
CC vs. CG+GG | 0.848 | <0.001 | Fixed | 1.157 (0.910-1.472) | 0.235 | |
CC+CG vs. GG | <0.001 | 89.184 | Random | 1.264 (0.503-3.174) | 0.619 | |
Gallbladder cancer | C vs. G | 0.015 | 83.061 | Random | 1.108 (0.710-1.728) | 0.652 |
CC vs. CG+GG | 0.029 | 78.918 | Random | 1.080 (0.644-1.812) | 0.771 | |
CC+CG vs. GG | 0.074 | 68.567 | Fixed | 1.099 (0.761-1.585) | 0.615 | |
Gastric cancer | C vs. G | 0.075 | 49.976 | Fixed | 1.010 (0.904-1.129) | 0.855 |
CC vs. CG+GG | 0.561 | <0.001 | Fixed | 0.977 (0.811-1.176) | 0.802 | |
CC+CG vs. GG | 0.012 | 65.907 | Random | 1.232 (0.823-1.843) | 0.311 | |
Esophageal cancer | C vs. G | 0.837 | <0.001 | Fixed | 1.087 (0.980-1.205) | 0.113 |
CC vs. CG+GG | 0.733 | <0.001 | Fixed | 1.017 (0.875-1.182) | 0.821 | |
CC+CG vs. GG | 0.031 | 56.757 | Random | 1.277 (0.939-1.735) | 0.119 | |
Head and neck cancer | C vs. G | 0.020 | 81.661 | Random | 1.499 (0.729-3.084) | 0.271 |
CC vs. CG+GG | 0.274 | 16.259 | Fixed | 1.856 (1.262-2.731) | 0.002 | |
CC+CG vs. GG | 0.124 | 57.636 | Fixed | 0.964 (0.696-1.335) | 0.825 | |
Hepatocellular cancer | C vs. G | 0.001 | 74.985 | Random | 1.089 (0.883-1.344) | 0.424 |
CC vs. CG+GG | <0.001 | 89.658 | Random | 1.113 (0.673-1.841) | 0.677 | |
CC+CG vs. GG | <0.001 | 85.472 | Random | 1.126 (0.723-1.754) | 0.600 |
OR odds ratio, vs versus. Bold numbers indicate significant association with risk of cancer.