Table 1. Distribution of allelic family and size variations of vaccine candidate genes in Indian P. falciparum isolates.
| Genes (n) |
Allelic family type | No. of samples | Percentage | No. of variants | Allele Size | Standard strain (amino acid) | MOI |
|---|---|---|---|---|---|---|---|
|
pfmsp1 (131) |
K1 | 42 | 32.06 | 21 | 148.48 ± 8.99* (132–171) |
3D7 (133) | 1.67 |
| MAD20 | 55 | 41.98 | 26 | 143.18 ± 8.61* (126–156) |
HN2 (127) | ||
| RO33 | 34 | 25.95 | 8 | 132.00 ± 0.00 (132–132) |
RO33 (132) | ||
| Mixed | 48 | ||||||
|
pfmsp2 (112) |
3D7/IC1 | 87 | 77.68 | 38 | 210.46 ± 11.69* (193–248) |
3D7 (245) | 1.28 |
| FC27 | 25 | 22.32 | 12 | 191.04 ± 10.86* (184–225) |
IGH-CR14 (185) | ||
| Mixed | 31 | ||||||
|
pfglurp (115) |
- | - | - | 59 | 257.04 ± 28.31* (156–317) |
3D7 (303) | |
|
pfcsp (97) |
- | - | - | 22 | 289.30 ± 15.24* (266–321) |
3D7 (277) | |
|
pfs25 (155) |
Wild type | 84 | 54.29 | - | 155 | 3D7 (155) | |
| A131G | 45 | 29.03 | - | 155 | 3D7 (155) | ||
| V143A | 26 | 16.77 | - | 155 | 3D7 (155) |
* P<0.05