Author, year	Citation	Description/significance
Hogben and Sim, 1953	Hogben L, Sim M (1953). The self-controlled and self-recorded clinical trial for low-grade morbidity. Br J Prev Soc Med 7:163–179.
Hare, 1955	Hare EH (1955). Comparative efficacy of hypnotics: a self-controlled, self-recorded clinical trial in neurotic patients. British Journal of Preventive and Social Medicine 9:140–146.
Guyatt, 1986	Guyatt G, Sackett D, Taylor DW, Ghong J, Roberts R, Pugsley S (1986). Determining Optimal Therapy – – Randomized Trials in Individual Patients. N Engl J Med 314:889-892.	N-of-1 trials are first brought to the attention of a wide medical readership
Guyatt, 1988	Guyatt G, Sackett D, Adachi J, Roberts R, Chong J (1988). A clinician’s guide for conducting randomized trials in individual patients. CMAJ 139: 497–503.	The practical approach presented encourages clinicians to conduct N-of-1 trials
Guyatt, 1990	Guyatt GH, Keller JL, Jaeschke R, Rosenbloom D, Adachi JD, Newhouse MT (1990b). The n-of-1 randomized controlled trial: clinical usefulness. Our three-year experience. Ann Intern 112:293–299.	Results of the first N-of-1 trial clinical service
Guyatt, 1990	Guyatt GGH, Heyting A, Jaeschke R, Keller J, Adachi JD, Roberts RS (1990a). N of 1 randomized trials for investigating new drugs. Control Clin Trials 11:88–100.	A proposal that individual N-of-1 randomised controlled trials could be used to elucidate drug effects at an early stage of development
Molloy, 1991	Molloy DW, Guyatt GH, Wilson DB, Duke R, Rees L, Singer J (1991). Effect of tetrahydroaminoacridine on cognition, function and behaviour in Alzheimer’s disease. CMAJ 144:29–34.	Early use of multiple N-of-1 trials in a particular condition to address drug effectiveness
Zucker, 1997	Zucker DR, Schmid CH, McIntosh MW, D’Agostino RB, Selker HP, Lau J (1997). Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment. J Clin Epidemiol 50:401–410.	Using Bayesian technique to combine N-of-1 trials
Guyatt et al., 2000	Guyatt G, Haynes RB, Jaeschke RZ, Cook DJ, Naylor CD, Wilson MC, Richardson WS (2000). Users; guide to the medical literature: XXV. Evidence-based medicine: principles for applying the users’ guides to patient care. Evidence-Based Medicine Working Group. JAMA 284:1290–96.	N-of-1 trial described as top of methodological hierarchy for informing treatment decisions
Guyatt, 2002	Guyatt G, Zhang Y, Jaeschke R, McGinn T (2002). Therapy and Validity: N of 1 Randomized Controlled Trials. Users’ Guides to the Medical Literature: A manual for Evidence-Based Clinical Practice. Chicago, IL: American Medical Association 275–290.	Users’ guide to N-of-1 trials
Nikles, 2006	Nikles C, Mitchell G, Mar C Del, Clavarino A, McNairn N (2006). An N of 1 trial service in clinical practice: Testing the effectiveness of stimulants for attention-deficit/ hyperactivity disorder. Pediatrics 2006;117:2040–2046.	One of the largest series of N-of-1 trials carried out in children with ADHD -carried out by a National Service to support the conduct of N-of-1 trials (the first ever) in Australia
Zucker, 2006	Zucker DR, Ruthazer R, Schmid CH, Feuer JM, Fischer PA, Kieval RI, Mogavero N, Rapoport RJ, Selker HP, Stotsky SA, Winston E, Goldenberg DL (2006). Lessons learned combining N-of-1 trials to assess fibromyalgia therapies. J Rheumatol 33:2069–2077.	Using Bayesian technique to combine N-of-1 trials
Tate, 2008	Tate RL, McDonald S, Perdices M, Togher L, Schultz R, Savage S (2008). Rating the methodological quality of single-subject designs and N of 1 trials: Introducing the single-case experimental design (SCED) scale. Neuropsychol Rehabil 18:385–401.	Single-Case Experimental Design (SCED) Scale
Zucker, 2010	Zucker DR, Ruthazer R, Schmid CH (2010). Individual (N of 1) trials can be combined to give population comparative treatment effect estimates: methodological considerations. Journal of Clinical Epidemiology 63:1312–1323.	Using Bayesian technique to combine N-of-1 trials
Gabler, 2011	Gabler NB, Duan N, Vohra S, Kravitz RL (2011). N-of-1 Trials in the Medical Literature: a systematic review. Med Care 49:761–768.	Systematic overview of the N-of-1 literature
OCEBM, 2011	OCEBM Levels of Evidence Working Group*. “The Oxford Levels of Evidence 2”. Oxford Centre for Evidence-Based Medicine. http://www.cebm.net/index.aspx?o=5653	N-of-1 trials are considered level 1 evidence by the Oxford Centre for Evidence-Based Medicine
Tate, 2013	Tate RL, Perdices M, Rosenkoetter U, Wakim D, Godbee K, Togher L, McDonald S (2013). Revision of a method quality rating scale for single-case experimental designs and N of 1 trials: The 15-item Risk of Bias in N of 1 Trials (RoBiNT) Scale. Neuropsychological Rehabilitation 23:619–38.	15-item Risk of Bias in N-of-1 Trials (RoBiNT) Scale
DEcIDE Methods Center N of 1 Guidance Panel, 2014	Kravitz RL, Duan N, eds, and the DEcIDE Methods Center N of 1 Guidance Panel (Duan N, Eslick I, Gabler NB, Kaplan HC, Kravitz RL, Larson EB, Pace WD, Schmid CH, Sim I, Vohra S) (2014). Design and Implementation of N of 1 Trials: A User’s Guide. AHRQ Publication No. 13(14)-EHC122-EF. Rockville, MD: Agency for Healthcare Research and Quality; February 2014. www.effectivehealthcare.ahrq.gov/N-1-Trials.cfm.	N-of-1 AHRQ Publication
Tate, 2014	Tate RL, Perdices M, McDonald S, Togher L, Rosenkoetter U (2014). The design, conduct and report of single-case research: Resources to improve the quality of the neurorehabilitation literature. Neuropsychological Rehabilitation 2014;24:315–31.	Reporting guidelines: Risk of Bias in N of 1 Trials (RoBiNT) Scale; Single-Case Reporting guideline In BEhavioural interventions (SCRIBE)
Shamseer, 2015	Shamseer L, Sampson M, Bukutu C, et al. CONSORT extension for reporting N of 1 trials (CENT) 2015: Explanation and elaboration. BMJ 2015;350:18–46	CENT explanation and elaboration
Vohra, 2015	Vohra S, Shamseer L, Sampson M, Bukutu C, Schmid CH, Tate R, Nikles J, Zucker DR, Kravitz R, Guyatt G, Altman DG, Moher D, CENT group (2015). CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement. BMJ 350:h1738	CENT checklist
Punja, 2016	Punja S, Bukutu C, Shamseer L, Sampson M, Hartling L, Urichuk L, Vohra S (2016c). N-of-1 trials are a tapestry of heterogeneity. J Clin Epidemiol 76:47–56	A systematic review of the methods of design, analysis, and meta–analysis used in published N-of-1 trials
Punja, 2016	Punja S, Schmid CH, Hartling L, Urichuk L, Nikles CJ, Vohra S (2016). To meta-analyze or not to meta-analyze? A combined meta-analysis of N of 1 trial data with RCT data on amphetamines and methylphenidate for pediatric ADHD. J Clin Epidemiol 76:76–81.	Combined meta-analysis of N-of-1 trials with randomised controlled trial data
Punja, 2016	Punja S, Xu D, Schmid CH, Hartling L, Urichuk L, Nikles CJ, Vohra S (2016a). N of 1 trials can be aggregated to generate group mean treatment effects: A systematic review and meta-analysis. J Clin Epidemiol 76:65–75.	Meta-analysis of N-of-1 trials
Tate, 2016	Tate RL, Perdices M, Rosenkoetter U, Shadish W, Vohra S, Barlow DH, Horner R, Kazdin A, Kratochwill T, McDonald S, Sampson M, Shamseer L, Togher L, Albin R, Backman C, Douglas J, Evans JJ, Gast D, Manolov R, Mitchell G, Nickels L, Nikles J, Ownsworth T, Rose M, Schmid CH and Wilson B (2016). The Single-Case Reporting Guideline In BEhavioural Interventions (SCRIBE) 2016 Statement. J Clin Epidemiol 73:142–152.	Provides authors, readers and reviewers of single case design studies with a tool to maximise clarity, transparency and completeness in reports of such trials