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. 2017 Jul 31;11:2239–2250. doi: 10.2147/DDDT.S137934

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© 2017 Allison Logan et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Release profile of OP (•) and GEM (■) from inner/outer OPⁱⁿ/GEM^out (A) and GEMⁱⁿ/OP^out (B) double-layered PLGA cylinders in comparison to the projected theoretical release of OP (- - -) and GEM (—), which assumes a constant release rate over 30 days.

Notes: The projected theoretical release rate was calculated from injected treatment doses of the two drugs shown effective in either the stagnation or reduction of tumor volume in a heterotopic xenograft model of human pancreatic cancer in mice (unpublished data, Szewczuk’s lab, August 2016).

Abbreviations: GEM, gemcitabine; OP, oseltamivir phosphate.