Figure 6.

Immune-related gene expressions in spleen cells of bare polyethylenimine (PEI)-treated mice as compared to reporter plasmid-conjugated PEI-immunized mice. The mRNA levels are shown as adjusted intensities for each gene. (A) Upregulated markers for the Th1 and Th2 responses. (B) Genes of the adaptive and innate immune responses. (C) Upregulated genes involved in immunogenicity and immunostimulation. Adapted by permission from Macmillan Publishers Ltd: Gene Ther. Regnström K, Ragnarsson EG, Köping-Höggård M, Torstensson E, Nyblom H, Artursson P. PEI – a potent, but not harmless, mucosal immuno-stimulator of mixed T-helper cell response and FasL-mediated cell death in mice. Gene Ther. 2003;10(18):1575–1583. copyright 2003.⁸⁶