Figure 7.

PEI-induced IL-12 secretion of macrophages was inhibited by TLR4 antibody. In contrast, the addition of isotype control antibody did not inhibit such IL-12 production significantly. Reprinted from Biomaterials, 2010;31(32), Chen H, Li P, Yin Y, et al, The promotion of type 1 T helper cell responses to cationic polymers in vivo via toll-like receptor-4 mediated IL-12 secretion. 8172–8180, Copyright (2010), with permission from Elsevier.¹⁰⁸

Abbreviations: PEI, polyethylenimine; IL-12, interleukin-12; TLR4, Toll-like receptor 4.