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. 2017 Aug 2;12:5537–5556. doi: 10.2147/IJN.S141145

Figure 2.

Figure 2

In vivo imaging of mice injected with (A) micelles of (i) PS80–EtOH DilC18, (ii) DSPE-PEG DilC18, (iii) DSPE-PEG lactosyl DilC18, (B) nanoparticles of (i) PLGA DilC18, (ii) PLGA-Ga DilC18 and (iii) HA DilC18, with solutions on the same scale of fluorescence, 10 minutes after injection. At least three mice per condition were imaged in vivo. Scales: radiant efficiency in (p/second/cm2/sr)/(µW/cm2); min =7.02E7; max =4.14E9. (C) Ex vivo imaging of livers and spleens of mice injected with (i) PLGA DilC18, (ii) PLGA-Ga DilC18 and (iii) HA DilC18 1 hour after injection. At least two mice per condition were imaged. Scales: radiant efficiency in (p/second/cm2/sr)/(µW/cm2); min =1.11E8; max =6.5E8.

Abbreviations: DilC18, 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindodicarbocyanine; DSPE-PEG, 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-(carboxy(polyethylene glycol)-2000); EtOH, ethanol; Ga, galactosamine; PLGA, poly(lactic-co-glycolic) acid; PLGA-Ga, PLGA nanoparticles functionalized with Ga; HA, hyaluronic acid; PS80, polysorbate 80.