Figure 4.

(A) Median tumor volume (mm³) (n=4 for groups 1–2, n=6 for groups 3–5), (B) individual tumor volume (mm³) of groups 1–2 and 4–5, (C) individual tumor volume (mm³) of groups 1–2, 3 and 5, (D) Kaplan–Meier diagram of groups 1–2 and 4–5, and (E) Kaplan–Meier diagram of groups 1–2, 3 and 5. Difference between the PLGA-Ga BM and docetaxel alone groups was evaluated with a two-way ANOVA analysis and a Bonferroni post test, ***P-value <0.001. Arrows: injections (gray arrow PS80–EtOH BM or PLGA-Ga BM injections and black arrow docetaxel injections).

Abbreviations: BM, bergamottin; EtOH, ethanol; Ga, galactosamine; PLGA, poly(lactic-co-glycolic) acid; PLGA-Ga, PLGA nanoparticles functionalized with Ga; PS80, polysorbate 80.