Table 2.
Levels of soluble factors and microparticles
| Cytokine/factor | Control | NSCLC | p-value |
|---|---|---|---|
| n | 42 | 161 | |
| IL-6 (pg/mL) | 12.1±8.8 | 14.6±19.5 | NS |
| MCP-1 (pg/mL) | 467±161 | 529±127 | NS |
| RANTES (ng/mL) | 57.1±10.8 | 74.8±21.2 | <0.05 |
| sVCAM-1 (ng/mL) | 728±1318 | 1,188±397 | <0.05 |
| sE-selectin (ng/mL) | 66.5±11.7 | 87.5±20.2 | <0.05 |
| HMGB1 (ng/mL) | 7.5±1.8 | 13.8±3.2 | <0.01 |
| Ang-2 (pg/mL) | 1,093±398 | 1,569±728 | <0.05 |
| VEGF (pg/mL) | 421±88 | 584±128 | <0.05 |
| PAI-1 (ng/mL) | 14.1±4.7 | 24.9±5.6 | <0.01 |
| PDMP (U/mL) | 13.5±4.1 | 31.9±7.3 | <0.001 |
Notes: The p-values are for control versus NSCLC. Data are shown as mean ± SD.
Abbreviations: IL-6, interleukin-6; MCP-1, monocyte chemoattractant protein-1; RANTES, regulated on activation normally T-cell expressed and secreted; sVCAM-1, soluble vascular cell adhesion molecule-1; sE-selectin, soluble E-selectin; HMGB1, high-mobility group box-1; Ang-2, angiopoietin-2; VEGF, vascular endothelial growth factor; PAI-1, plasminogen activator inhibitor-1; PDMP, platelet-derived microparticle; NS, not significant; NSCLC, non-small-cell lung cancer; SD, standard deviation.