Table 5.

Multivariate analysis of overall survival

Covariate	HR	95% Cl	p-value
NDRF0 vs NDRF2 or 3	1.579	1.118–2.334	0.0013*
Age, ≤70 y vs ≥71 y	0.914	0.632–1.315	0.3146
Female vs. male	0.529	0.375–0.812	0.0011*
Non smokers vs smoker	1.028	0.679–1.536	0.7649
ECOG PS 0–2 vs. 3–4	0.374	0.217–0.534	<0.0001*
Non-sq vs. sq	0.593	0.296–0.975	0.0039*
Stage IIIb vs IV	0.582	0.413–0.872	0.0416*

Notes:

^*p<0.05. NDRF0: no high level of above markers; NDRF2: no fewer than two high levels of above markers; NDRF3: all high levels of above markers.

Abbreviations: NDRF, newly designed risk factor; ECOG, Eastern Cooperative Oncology Group; PS, performance status; sq, squamous cell carcinoma; HR, hazard ratio; CI, confidence interval.