Table 2.
MODY SNPs Associated With Log Baseline InsIndex at P < 3 × 10–4 and Their Association With Log Baseline DIo and Insulin Sensitivity (Log 1/FI)
| Gene | SNP | Alleles (Effect/Other) | Log Baseline InsIndex | Log Baseline DIo | Log Baseline 1/FI | Diabetes Incidence | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β (SE) | P Value | Genotype (n) | Adjusted Means (95% CI) | β (SE) | P Value | β (SE) | P Value | HR (95% CI) | P Value | |||
| NEUROD1 | rs11884960 | A/G (MAF = 2.2%) | 0.084 (0.023) | 3 × 10–4 | GG (3291) | 1.200 (1.149–1.252) | 0.065 (0.034) | 0.06 | –0.065 (0.044) | 0.14 | 0.71 (0.48–1.07) | 0.10 |
| AG (135) | 1.502 (1.332–1.681) | |||||||||||
| AA (9) | 1.501 (0.940–2.177) | |||||||||||
| PDX1 | rs4769581 | T/C (MAF = 39%) | 0.027 (0.007) | 2 × 10–4 | CC (1267) | 1.149 (1.086–1.213) | 0.026 (0.0105) | 0.01 | –0.005 (0.0134) | 0.71 | 1.0 (0.88–1.13) | 1.0 |
| TC (1666) | 1.223 (1.164–1.283) | |||||||||||
| TT (506) | 1.317 (1.230–1.407) | |||||||||||
| HNF1B | rs3110638 | A/G (MAF = 0.83%) | 0.145 (0.038) | 1 × 10–4 | GG (3376) | 1.933 (0.342–4.689) | 0.182 (0.0557) | 0.001 | 0.034 (0.0716) | 0.64 | 0.86 (0.45–1.6) | 0.64 |
| AG (55) | 1.691 (1.426–1.977) | |||||||||||
| AA (1) | 1.207 (1.156–1.259) | |||||||||||
The underlined alleles designate the minor allele. The adjusted means are back-transformed for InsIndex. Supplemental Table 3 (173.4KB, xlsx) shows the association of all the SNPs examined and baseline insulinogenic traits.
Abbreviations: FI, fasting insulin; HR, hazard ratio; β (SE), β estimate (standard error) of the association of each minor allele with the respective trait.