Table 4.
Replication of Previously Reported Type 2 Diabetes–Associated MODY Genetic Variants for Association With Diabetes Incidence in the DPP
| SNP | Effect/Other | Gene | ORa (95% CI) | Proxy (Effect/Other)b | r2 (CEU) | Diabetes HR (95% CI) | P Value |
|---|---|---|---|---|---|---|---|
| rs2244164 (9) | C/T | GCK | 0.81 (0.72–0.92) | rs2080033 (C/T) | 1 | 1.05 (0.93–1.18) | 0.42 |
| rs1169288 (11) | T/G | HNF1A | 1.20 (1.10–1.3)a | 0.99 (0.87–1.12) | 0.89 | ||
| rs2701175 (9) | C/A | HNF1A | 1.34 (1.06–1.68) | rs1169288 (G/T) | 0.6 | 1.01 (0.89–1.15) | 0.89 |
| rs2071190 (9) | A/T | HNF1A | 2.08 (1.30–3.31) | 1.10 (0.96–1.27) | 0.15 | ||
| rs7305618a (18) | C/T | HNF1A | 1.14 (1.09–1.20) | 0.98 (0.86–1.12) | 0.80 | ||
| rs7957197a (17) | T/A | HNF1A | 1.07 (1.05–1.10) | rs7305618 (G/A) | 0.57 | 0.98 (0.86–1.12) | 0.80 |
| rs11263755 (10) | A/G | HNF1B | 1.13 (1.04–1.23) | 0.92 (0.79–1.05) | 0.22 | ||
| rs2285741 (10) | A/G | HNF1B | 0.94 (0.88–1.00) | 0.89 (0.79–1.01) | 0.06 | ||
| rs2689 (10) | A/T | HNF1B | 1.09 (1.02–1.17) | 1.08 (0.96–1.22) | 0.19 | ||
| rs3110641 (10) | C/T | HNF1B | 1.10 (1.04–1.17) | 0.96 (0.85–1.1) | 0.57 | ||
| rs3094513 (10) | T/C | HNF1B | 1.08 (1.01–1.16) | rs3110640 (C/T) | 0.93 | 1.09 (0.97–1.23) | 0.14 |
| rs757210 (10) | A/G | HNF1B | 1.12 (1.07–1.18) | 1.13 (1.01–1.27) | 0.04 | ||
| rs12450628 (9) | T/C | HNF1B | 1.63 (1.20–2.23) | rs2411153 (C/G) | 0.68 | 0.89 (0.80–1.00) | 0.06 |
| rs1008284 (9) | A/G | HNF1B | 0.53 (0.37–0.75) | 1.07 (0.94–1.22) | 0.32 | ||
| rs4430796a (17) | G/A | HNF1B | 1.14 (1.08–1.20) | 1.08 (0.96–1.21) | 0.17 | ||
| rs4810424 (11) | C /G | HNF4A | 1.30 (1.00–1.60)c | rs1884614 (A/G) | 0.95 | 1.04 (0.90–1.20) | 0.58 |
| rs3212198 (11) | C/T | HNF4A | 1.10 (1.00–1.20)c | 0.96 (0.86–1.08) | 0.54 | ||
| rs6103716 (9) | C/A | HNF4A | 1.26 (1.11–1.44) | 1.07 (0.95–1.21) | 0.25 | ||
| rs6017317a (20) | G/T | HNF4A | 1.09 (1.07–1.12) | rs1884614 (A/G) | 0.7 | 1.04 (0.90–1.20) | 0.58 |
| rs4812829a (19) | A/G | HNF4A | 1.09 (1.06–1.12) | rs1884614 (A/G) | 1 | 1.04 (0.90–1.20) | 0.58 |
| rs3916026 (9) | C/G | NEUROD1 | 0.73 (0.61–0.87) | 1.00 (0.88–1.12) | 0.94 | ||
| rs2297316d (9) | A/G | PDX1 | 0.77 (0.64–0.92) | — | — |
The article origin for each SNP is in parentheses to the right of the SNP.
Abbreviations: HR, hazard ratio; OR, odds ratio.
a
SNPs found to be associated with type 2 diabetes in GWASs.
b
Proxy alleles are consistent with the major or minor effect allele in the original study.
c
The effect represents a hazard ratio.
d
rs2297316 did not have an adequate proxy (r2 > 0.5) genotyped in the DPP.