Figure 3.

Effects of soluble TGF-β receptors on TGF-β1 action. HEK293 cells were transfected with TGF-β–responsive luciferase reporter and treated with 10 pM TGF-β1 ligand in the presence or absence of soluble TGF-β receptors. TGF-β1–induced luciferase reading without any soluble receptor was set as 100%. The effect of soluble receptors was expressed as a percentage (mean ± standard deviation) of TGF-β1–induced luciferase activity from three independent experiments. (a) Dose responses of individual soluble TGF-β receptors on TGF-β1 action. (b) Effect of each soluble receptor alone at the highest concentration seen in early-onset PE serum on TGF-β1 action. (c) Effects of soluble TGF-β receptor combinations on TGF-β1 action. *P < 0.05. sEng, soluble endoglin; sRI, soluble TGFβRI; sRII, soluble TGFβRII; sRIII, soluble TGFβRIII.