Table 2.
Influence of SNPs on Progression to Multiple Abs in Single Ab-Positive (Ab+) Subjects (N = 239)
| Variable | HR (95% CI) | P Value |
|---|---|---|
| Age at initial screen | 0.89 (0.83 to 0.95) | 0.001 |
| Sex: male | 1.83 (0.82 to 4.09) | 0.141 |
| Offspring | 8.13 (1.00 to 66.43) | 0.051 |
| Parent | 47.59 (2.54 to 890.06) | 0.010 |
| Sibling | 4.66 (0.61 to 35.86) | 0.139 |
| HLA-DR3/3 | 3.98 (0.54 to 29.30) | 0.175 |
| HLA-DR3/4 | 8.26 (1.28 to 53.18) | 0.026 |
| HLA-DR3/Xa | 4.74 (0.88 to 25.57) | 0.071 |
| HLA-DR4/4 | 14.19 (2.24 to 90.04) | 0.005 |
| HLA-DR4/Xa | 4.58 (0.92 to 22.87) | 0.064 |
| IA-2A first | 0.80 (0.24 to 2.68) | 0.722 |
| IAA first | 0.63 (0.25 to 1.58) | 0.321 |
| rs3087243 (CTLA4) | 0.47 (0.28 to 0.80) | 0.005 |
Multivariate Cox proportional hazard model including the SNPs that were univariately substantial (P ≤ 0.10), age, sex, HLA-DR, relationship to proband, and type of first Ab. GADA is the reference group.
a
Where X equals not DR3, not DR4. HLA DR X/X (i.e., not 3/3, 3/4, 3/X, 4/4, or 4/X) is used as reference group.