Table 3.
Influence of SNPs on Progression to T1D in Ab-Positive (Ab+) Participants (N = 1016)
| Variable | HR (95% CI) | P Value |
|---|---|---|
| Age at initial screen | 0.98 (0.96 to 0.99) | 0.012 |
| Number Ab+ | 1.51 (1.04 to 2.19) | 0.030 |
| Sex: male | 1.24 (0.94 to 1.64) | 0.133 |
| Offspring | 1.34 (0.69 to 2.58) | 0.383 |
| Parent | 0.73 (0.29 to 1.82) | 0.449 |
| Sibling | 1.37 (0.74 to 2.55) | 0.321 |
| HLA-DR3/3 | 2.04 (0.85 to 4.89) | 0.109 |
| HLA-DR3/4 | 3.12 (1.55 to 6.28) | 0.001 |
| HLA-DR3/Xa | 1.60 (0.76 to 3.39) | 0.219 |
| HLA-DR4/4 | 2.78 (1.28 to 6.02) | 0.010 |
| HLA-DR4/Xa | 2.00 (1.00 to 4.01) | 0.051 |
| rs6476839 (GLIS3) | 1.29 (1.05 to 1.57) | 0.013 |
| rs3184504 (SH2B3) | 1.23 (1.01 to 1.48) | 0.035 |
Multivariate Cox proportional hazard model including the SNPs that were univariately substantial (P ≤ 0.10), age, sex, HLA-DR, relationship to proband, and number of Abs.
a
Where X equals not DR3, not DR4. HLA DR X/X (i.e., not 3/3, 3/4, 3/X, 4/4, or 4/X) is used as reference group.