Table 2.
Cross-Sectional Markers of Bone and Renal Health
| HIV+ (n = 65) | Control (n = 23) | P Value | |
|---|---|---|---|
| Bone density | |||
| Whole-body BMD, g/cm2 | 1.15 (1.08, 1.22) | 1.21 (1.16, 1.28) | 0.005 |
| Whole-body BMD z score | −0.2 (-1.1, 0.6) | 0.4 (-0.2, 1.1) | 0.02 |
| Whole-body lean mass, kg | 45.9 (39.3, 52.8) | 48.6 (40.8, 61.7) | 0.2 |
| Lumbar spine BMD, g/cm2 | 1.03 (0.94, 1.14) | 1.08 (0.99, 1.12) | 0.31 |
| Lumbar spine z score | −0.5 (-1.3, 0.4) | −0.3 (-0.8, 0.3) | 0.42 |
| Bone parameters | |||
| 25-Hydroxyvitamin D, ng/mL | 23 (16, 32) | 21 (17, 33) | 0.96 |
| NTx, nmol/mmol | 52 (34, 70) | 32 (18, 54) | 0.01 |
| Alkaline phosphatase, U/L | 76 (62, 93) | 70 (53, 83) | 0.05 |
| Osteocalcin, ng/mL | 30.1 (23.4, 39.6) | 22.1 (15.2, 25.5) | 0.007 |
| PTH, pg/mL | 40 (34.3, 53.4) | 35.4 (29.7, 38.9) | 0.03 |
| Phosphorus, inorganic, mg/dL | 3.3 (3, 3.7) | 3.6 (3.2, 3.9) | 0.1 |
| Calcium, mmol/L | 2.27 (2.18, 2.35) | 2.31 (2.28, 2.38) | 0.03 |
| Thyroid-stimulating hormone, mcIU/mL | 1.37 (0.88, 2.08) | 1.81 (1.17, 2.67) | 0.19 |
| Renal parameters | |||
| eGFR, mL/min/1.73m2 | 129 (116, 142) | 119 (113, 124) | 0.02 |
| Proteinuria, n (%) | 2 (3) | 0 (0) | 0.39 |
| Microalbuminuria, n (%) | 5 (9) | 2 (9) | 0.95 |
| Urinary ACR, mg/g | 6.9 (4.6, 15.3) | 4.4 (3, 6.1) | 0.002 |
| Urinary PCR, mg/mg | 0.13 (0.11, 0.17) | 0.09 (0.07, 0.13) | 0.004 |
| Creatinine, mg/dL | 0.71 (0.64, 0.84) | 0.81 (0.72, 0.98) | 0.02 |
| Anion gap, mEq/L | 10 (9, 13) | 8 (7, 11) | 0.02 |
| Bicarbonate, mmol/L | 25 (23, 26) | 26 (24, 29) | 0.02 |
| Glucosuria, n (%) | 2 (3) | 1 (4) | 0.84 |
Values are expressed as median (IQR). Boldface indicates significant P values (<0.05). Lumbar spine available on n = 56 HIV, n = 22 control.