Table 3.
Longitudinal Markers of Bone and Renal Health in HIV-Infected Subjects (n = 33)
| Baseline | Follow-Up | Mean Difference | P Value | |
|---|---|---|---|---|
| Bone density | ||||
| Whole-body BMD, g/cm2 | 1.07 ± 0.02 | 1.16 ± 0.02 | 0.08 ± 0.01 | <0.0001 |
| Whole-body BMD z score | −0.69 ± 0.2 | −0.25 ± 0.2 | 0.4 ± 0.1 | <0.0001 |
| Lumbar spine BMD, g/cm2 | 0.97 ± 0.02 | 1.04 ± 0.02 | 0.06 ± 0.01 | 0.0001 |
| Lumbar spine z score | −0.41 ± 0.18 | −0.38 ± 0.19 | 0 ± 0.1 | 1 |
| Bone parameters | ||||
| 25-Hydroxyvitamin D, ng/mL | 28.8 ± 2.8 | 28.8 ± 2.5 | 0.07 ± 2.7 | 0.98 |
| NTx, nmol/mmol | 135.9 ± 34.4 | 57.7 ± 5.6 | −78.2 ± 32.1 | 0.02 |
| Alkaline phosphatase, U/L | 122.6 ± 18.5 | 81.2 ± 3.6 | −41.4 ± 17.4 | 0.02 |
| Osteocalcin, ng/mL | 55.8 ± 10.5 | 34 ± 2.9 | −21.8 ± 9.5 | 0.03 |
| Phosphorus, inorganic, mg/dL | 4.1 ± 0.1 | 3.5 ± 0.1 | −0.7 ± 0.1 | <0.0001 |
| Calcium, mmol/L | 2.3 ± 0.01 | 2.2 ± 0.02 | −0.1 ± 0.02 | <0.0001 |
| Renal parameters | ||||
| eGFR, mL/min/1.73m2 | 129.2 ± 4.4 | 128.2 ± 3.5 | −1.03 ± 2.8 | 0.71 |
| Urinary ACR, mg/g | 19.3 ± 6.3 | 34.6 ± 21.7 | 15.2 ± 18.3 | 0.41 |
| Urinary PCR, mg/mg | 0.14 ± 0.02 | 0.16 ± 0.02 | 0.02 ± 0.03 | 0.45 |
| Creatinine, mg/dL | 0.78 ± 0.03 | 0.76 ± 0.03 | −0.02 ± 0.02 | 0.35 |
| Anion gap, mEq/L | 6.8 ± 0.4 | 9.7 ± 0.4 | 2.9 ± 0.6 | <0.0001 |
| Bicarbonate, mmol/L | 26.7 ± 0.35 | 25.1 ± 0.45 | −1.6 ± 0.4 | 0.0005 |
Values are expressed as mean (standard error) unless indicated otherwise. Boldface indicates significant P values (<0.05).