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Three siRNA sequences for each gene (MMP3, CCL12, and HIF1A) were selected and tested for the suppression of the targeted mRNAs. A549 human aveolar basal epithelial adenocarcinoma lung cells were incubated with siRNAs delivered by NLC. Gene expression was measured by the QPCR and presented as fold change relative to the untreated cells. Means ± SD are shown. *The most efficient siRNA sequences chosen for the further in vivo study.
