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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Nanomedicine. 2017 Apr 19;13(6):1983–1992. doi: 10.1016/j.nano.2017.04.005

Figure 5. Expression of targeted genes in lung tissues of mice with pulmonary fibrosis.

Figure 5

Pulmonary fibrosis was induced by intratracheal instillation of 1.5 U/kg of bleomycin. Mice were treated with substances indicated twice a week for three weeks starting one day later after the bleomycin administration. At the end of treatment, lungs were harvested and homogenized. The expression of MMP3 (A), CCL12 (B) and HIF1A (C) genes was measured by the QPCR and presented as fold change relative to the healthy animals. Means ± SD are shown. *P < 0.05 when compared with control mice; † P < 0.05 when compared with untreated mice with pulmonary fibrosis.