Table 5.

Results of biometric model fitting of AUD and MDD at T1 and T2.

#	Model	ep	AIC	sBIC	Δ−2LL	Δdf	p
	Step 1
1	Qualitative sex differences, ACE	86	−7073.16	13455.27	-	-	-
2	Qualitative sex differences, AE	66	−7084.35	13390.59	16.814	14	.266
3	Quantitative sex differences, ACE	76	−7092.32	13415.36	0.844	10	1.000
4	Quantitative sex differences, AE	56	−7092.91	13361.28	28.25	24	.250
5	Quantitative sex differences, CE	56	−7083.62	13370.57	37.54	24	.039
6	No sex differences, ACE	46	−7080.27	13321.17	28.89	18	.050
7	No sex differences, AE	36	−7098.88	13281.81	30.28	28	.350
8	No sex differences, CE	36	−7077.79	13302.90	51.36	28	.005
	Step 2
9	No A from MDD to AUD (a41=0)	35	−7100.63	13277.99	0.26	1	.611
10	No E from MDD to AUD (e41=0)	35	−7100.88	13277.73	0.00	1	.975
11	No A or E from MDD to AUD	34	−7102.49	13274.05	0.39	2	.822
12	No A from AUD to MDD (a32=0)	35	−7098.13	13280.49	2.76	1	.097
13	No E from AUD to MDD (e32=0)	35	−7100.47	13278.14	0.41	1	.521
14	No A or E from AUD to MDD	34	−7100.06	13276.48	2.82	2	.244
15	No prospective AE across disorders*	32	−7103.26	13269.13	3.63	4	.459
	Step 3
16	No new A in AUD (a44=0, ra43=0)	30	−7096.18	13272.07	11.08	2	.003
17	No new A in MDD (a33=0, ra43=0)**	30	−7107.01	13261.23	0.24	2	.885
	Step 4
18	No genetic correlation at T1 (ra21=0)	29	−7084.22	13281.95	24.79	1	<.001
19	No environmental correlation at T1 (re21=0)	29	−7108.81	13257.35	0.20	1	.656
20	No new environmental correlation (re43=0)	29	−7102.46	13263.71	6.56	1	.010
21	No environmental stability in MDD (e31=0)	29	−7108.75	13257.42	0.26	1	.608
22	No environmental stability in AUD (e42=0)	29	−7100.81	13265.35	8.20	1	.004
23	Stable environmental correlation (re21=re43)	29	−7105.54	13260.63	3.48	1	.062
24	re21=0 and e31=0**	28	−7110.42	13253.67	0.59	2	.744

Notes: ep = estimated parameters;

^*best fitting model in step;

^**overall best fitting model.

Models are compared to the best fitting model in the previous step.