aData strongest for European ancestry populations and consistent in most Japanese studies.
b“Dose clinically” means to dose without genetic information, which may include use of a clinical dosing algorithm or standard dose approach
cValidated published pediatric pharmacogenetic algorithms include Hamberg et al.(42) and Biss et al.(41)
dNo studies in children included CYP2C9*5, *6, *8, or *11 genotyping.