Fig. 1.
Measurement of tumor size. (A) Approximate tumor size in BALB/C nude animal models was calculated using the following formula: length (L) × width (W)2 × 0.5.
Changes of tumors volume in experimental models. Data are representatives of in vivo experiment. (B) BALB/c nude mice with dissected tumors. (C) The sizes of tumors during 3 weeks of growth; On week 1, week 2, and week 3, the tumor volume in group of M + S showed significant reduction compare to that in the control group. Among lonely used regimens, the most potent one was S.
CTL = control, S = sirolimus, T = tacrolimus, CsA = cyclosporin A, M = metformin, Met/S = metformin/sirolimus, Met/T = metformin/tacrolimus, Met/CsA = metformin/cyclosporine A.
*P < 0.05 compared to control.