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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: J Allergy Clin Immunol. 2017 Feb 21;140(2):454–464.e2. doi: 10.1016/j.jaci.2017.02.001

Figure 1. Synergistic anti-pruritic interaction of GABA-A and GABA-B receptor agonists.

Figure 1

(A) Baclofen, ≥ 3.0 mg/kg or muscimol, ≥ 1.5 mg/kg (red) are sedating. V: vehicle. Non-sedative baclofen or muscimol against histamine- (B), chloroquine- (C) and endothelin-1 (D). Co-administering non-sedative baclofen and muscimol against histamine (B) and endothelin-1 (D). Combined subthreshold baclofen and ED50 muscimol against chloroquine (C). Data: ± SEM; ** P<0.005, *** P<0.001; two-way ANOVA.