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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: J Allergy Clin Immunol. 2017 Feb 21;140(2):454–464.e2. doi: 10.1016/j.jaci.2017.02.001

Figure 2. A synergistic interaction of GABA-A and GABA-B receptors is anti-pruritic against chronic itch.

Figure 2

Compared to saline (black), systemic baclofen (red; A) or muscimol (B) in IL-31Tg mice is anti-pruritic. Systemic co-administration of subthreshold baclofen and muscimol synergize against spontaneous scratching and these doses are not sedating (C). Data: ± SEM; ** P<0.005, *** P<0.001; two-way ANOVA.