Table 2.
Descriptive statistics by imaging site
| Columbia | Harvard | Michigan | UTSW | ||||||
|---|---|---|---|---|---|---|---|---|---|
| MDD+ | MDD− | MDD+ | MDD− | MDD+ | MDD− | MDD+ | MDD− | ||
| n | n | n | n | n | n | N | n | Statistic | |
| Group | 44 | 12 | 34 | 17 | 33 | 9 | 59 | 14 | χ site (3) = 3.74, P = 0.29 |
| Course | χ site (3) = 6.18, P = 0.10 | ||||||||
| Recurrent | 36 | – | 26 | – | 32 | – | 51 | – | |
| Single episode | 8 | – | 8 | – | 1 | – | 8 | – | |
| Gender | χ site (3) = 2.59, P = 0.47 | ||||||||
| M | 21 | 4 | 16 | 8 | 11 | 3 | 20 | 8 | |
| F | 23 | 8 | 18 | 9 | 22 | 6 | 39 | 6 | |
| Education level | χ site (3) = 5.78, P = 0.12 | ||||||||
| ≥16 years | 26 | 7 | 15 | 9 | 14 | 5 | 21 | 8 | |
| < 16 years | 16 | 5 | 19 | 8 | 19 | 4 | 38 | 6 | |
| Lifetime psychopathology | |||||||||
| Panic disorder | 9 | 0 | 6 | 0 | 5 | 0 | 7 | 0 | χ site (3) = 1.40, P = 0.71 |
| OCD | 0 | 0 | 2 | 0 | 0 | 0 | 4 | 0 | χ site (3) = 5.20, P = 0.16 |
| Specific phobia | 8 | 0 | 6 | 0 | 11 | 0 | 7 | 0 | χ site (3) = 6.46, P = 0.09 |
| Social phobia | 2 | 0 | 0 | 0 | 4 | 0 | 9 | 0 | χ site (3) = 4.99, P = 0.17 |
| PTSD | 6 | 0 | 1 | 0 | 11 | 0 | 9 | 0 | χ site (3) = 11.97, P = 0.01 |
| Anorexia | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | χ site (3) = 1.39, P = 0.71 |
| Bulimia | 0 | 1 | 3 | 0 | 0 | 0 | 1 | 0 | χ site (3) = 5.51, P = 0.14 |
| Alcohol use disorder | 6 | 0 | 2 | 1 | 10 | 0 | 15 | 0 | χ site (3) = 8.78, P = 0.03 |
| Illicit use disorder | 5 | 1 | 3 | 0 | 6 | 0 | 12 | 0 | χ site (3) = 3.00, P = 0.39 |
|
Mean (SD) Range |
Mean (SD) Range |
Mean (SD) Range |
Mean (SD) Range |
Mean (SD) Range |
Mean (SD) Range |
Mean (SD) Range |
Mean (SD) Range |
||
| Number of episodes^& |
5.32 (6.23) 1–20 |
– |
6.18 (6.31) 1–20 |
– |
9.36 (6.74) 1–20 |
– |
9.14 (7.60) 1–20 |
– |
F site (3,166) = 2.85, P = 0.04, Post Hoc: M > C, M > H |
| Age |
34.45 (10.52) 18–61 |
36.92 (13.23) 18–64 |
35.44 (14.69) 18–60 |
39.24 (18.46) 18–65 |
34.36 (13.11) 18–58 |
43.78 (15.19) 23–62 |
41.37 (11.40) 19–63 |
32.71 (11.75) 20–57 |
F site (3,214) = 0.37, P = 0.77, F DX (1,214) = 0.69, P = 0.41, F int (3,214) = 3.30, P = 0.02 |
| Total brain volume* |
1.15 (0.14) 0.85–1.54 |
1.14 (0.13) 0.99–1.44) |
1.12 (0.10) 0.91–1.41 |
1.12 (0.11) 0.87–1.29 |
1.12 (0.12) 0.92–1.43 |
1.09 (0.15) 0.90–1.28 |
1.11 (0.11) 0.85–1.39 |
1.19 (0.16) 0.97–1.54 |
F site (3,214) = 1.23, P = 0.30, F DX (1,214) = 0.24, P = 0.62, F int (3,214) = 1.82, P = 0.14 |
| Quick inventory of depression symptoms |
19.00 (2.98) 14–24 |
1.50 (1.13) 0–4 |
17.65 (2.89) 14–27 |
1.12 (1.05) 0–3 |
18.67 (3.27) 14–27 |
2.22 (1.99) 0–6 |
17.28 (2.43) 14–24 |
1.14 (1.29) 0–4 |
F site (3, 213) = 2.11, P = 0.10, F DX (1,213) = 1,561, P < 0.01, F int (3,213) = 0.51, P = 0.68 |
Note: ^ = for ANOVA, data was log10 +1 transformed due to positive skew; & = data were windsored to 20 for reporting descriptive statistics. * = 105 and millimeters3 2 participants at Columbia declined to report education.