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. 2017 Aug 7;7:7454. doi: 10.1038/s41598-017-07614-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Detection of nascent phospholipids during NR formation by pulse labelling with deuterated stearate. (a) Representative backscattered electron (BSE) image of a saquinavir-treated mouse preadipocyte with black arrows indicating NR tubules with a corresponding image from NanoSIMS showing enrichment of deuterium signal (²H/¹H ratio) indicating nascent fatty acyl species, also at the NR foci (indicated with white arrows); black arrowheads in BSE image correspond to NR presumably present in the nucleus prior to ²H pulse, hence not showing enrichment in deuterium signal in the NanoSIMS image (white arroheads). (b) BSE and NanoSIMS images of a control cell treated with DMSO vehicle showing lack of NR tubules and no deuterium enrichment within the nucleus, and undistorted nuclear boundary. Colour scale of NanoSIMS images 2–400 equals 0.02–4% of ²H/¹H.