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. 2017 Aug 7;7:7471. doi: 10.1038/s41598-017-08264-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The adoptive transfer of normal alveolar macrophages or CCL24 neutralization rescues anti-tumor immune impairment in Abt mice. The mice were given antibiotics for five weeks and then challenged with B16/F10 cells (1 × 10⁵ cells/mouse, i.v.). Alveolar macrophages transfer and CCL24 neutralization were performed in the Abt mice. The mice were treated with antibiotics for the entire experimental period. (a) The lungs were analyzed on day 17 after the B16/F10 melanoma challenge. The graphs showed the total number of tumor colonies present in the lung lobes, and the numbers of tumor foci in the lungs were calculated. (b) The total number of MNCs in the lungs on day 17 after the B16/F10 challenge. (c) The frequency of γδT cells among lymphocytes in the lungs, and the absolute number were shown. The isolated MNCs were analyzed by FACS and the lymphocytes were gated by FSC and SSC. (d) The frequency of IL-17A⁺ γδT cells and IFN-γ⁺ γδT cells among total γδT cells in the lungs, and their absolute numbers were shown. There were six mice in each group. The data are shown as the mean ± SEM. *p < 0.05 compared with the control group.