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. 2017 Aug 7;7:7433. doi: 10.1038/s41598-017-07964-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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JAM-A indicated B-lymphoma cell stemness. (A) As assessed by Whole-mount in Situ Hybridization and real-time quantitative RT-PCR, c-myb and runx1 were overexpressed after 26 h microinjecting jam-1 mRNA (jam-1) in Zebrafish embryos. WT, wild type. (B,C) B-lymphoma cell line DB and SU-DHL-4 were transfected with control vector (Vector) and JAM-A vector (JAM-A). Ectopic expression of JAM-A was associated with increased colony formation (B) and stem-cell marker CD133 and CD34 expression (C). (D) DLBCL patients with high JAM-A expression displayed increased CD133 positivity. (E) Patients in high JAM-A expression group were enriched for a stem cell gene signature, as revealed by RNA sequencing. Data in (A), (B) and (C) are representative of three independent experiments.